Effect of geraniin on aminonucleoside nephrosis in rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of geraniin (Ger), a tannin extracted from the herb Geranium thunbergii Sieb et Zucc, on puromycin aminonucleoside (PA) nephrosis were studied in rats. The urine protein excretion in female rats (140-160 g) receiving PA (50mg/kg) alone was significantly elevated on the 7th day after the injection of PA and reached its maximum on the 14th day, but in the animals treated intramuscularly with Ger (1Omg/kg) the urinary protein on the 14th was reduced to approximately 35%. The increases in serum cholesterol and lipid peroxide produced by PA treatment were also suppressed by Ger. Observation by electron microscopy revealed that the degree of abnormality in glomerular epithelial cells, i.e., the loss of fusion of foot processes, was lower in the rats treated with Ger after the PA injection than in the rats treated with PA alone. Moreover, pretreatment with Ger did not suppress the urinary protein excretion, but when it was given 9 days after PA, a significant decrease in urinary protein excretion was observed. The increases in serum cholesterol and lipid peroxide were suppressed by neither pretreatment nor posttreatment with Ger.
- 日本生薬学会の論文
- 1999-04-20
著者
-
Nakanishi Y
Kinki Univ. Osaka Jpn
-
Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
-
Okuda T
Okayama Univ. Okayama Jpn
-
Okuda Takuo
Faculty Of Pharmaceutical Sciences Okayama University
-
Abe Hiroko
First Department Research Institute Of Oriental Medicine Kinki University
-
NAKANISHI Yuka
First Department, Research Institute of Oriental Medicine, Kinki University
-
Nakanishi Yuka
First Department Research Institute Of Oriental Medicine Kinki University
-
Kubo M
Faculty Of Pharmaceutical Sciences Kinki University
-
Okuda Takuo
Faculty of Pharmaceutical Science, Okayama University
関連論文
- Studies on Kochiae Fructus. V. Antipruritic Effects of Oleanolic Acid Glycosides and the Structure-Requirement
- Studies on Kochiae Fructus IV. Anti-Allergic Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus III. Antinociceptive and Antiinflammatory Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus. II. On the Saponin Constituents from the Fruit of Chinese Kochia scoparia (Chenopodiaceae) : Chemical Structures of Kochianosides I, II, III, and IV
- Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang
- Anti-allergic Effects of Cnidii Monnieri Fructus (Dried Fruits of Cnidium monnieri) and Its Major Component, Osthol
- Study on Anti-Oketsu Activity of Rhubarb II. Anti-allergic Effects of Stillbene Components from Rhei undulati Rhizoma(Dried Rhizome of Rheum undulatum Cultivated in Korea)
- Studies on Alismatis Rhizoma. III. Stereostructures of New Protostane-Type Triterpenes, Alisols H, I, J-23-Acetate, K-23-Acetate, L-23-Acetate, M-23-Acetate, and N-23-Acetate, from the Dried Rhizome of Alisma orientale
- Studies on Alismatis Rhizoma. II. Anti-complementary Activities of Methanol Extract and Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale)
- NOVEL iNDOLE S, O-BISDESMOSIDE, CALANTHOSIDE, THE PRECURSOR GLYCOSIDE OF TRYPTANTHRIN, INDIRUBIN, AND ISATIN, WITH INCREASING SKIN BLOOD FLOW PROMOTING EFFECTS, FROM TWO CALANTHE SPECIES (ORCHIDACEAE)
- Studies on Alismatis Rhizoma. I. Anti-allergic effects of Methanol Extract and Six Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale)
- Antinociceptive Activities of 70% methanol Extract of Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components
- Studies of Cuticle Drugs from Natural Sources. IV. Inhibitory Effects of Some Arctostaphylos Plants on Melanin Biosynthesis
- Inhibitory Effects of Dehydrocorydaline Isolated from Corydalis Tuber against Type I-IV Allergic Models
- Anti-inflammatory Activities of 70% Methanolic Extract from Cinnamomi Cortex
- Pharmacological Study on Agkistrodon blomhoffii blomhoffii BOIE. V. Anti-fatigue Effect of the 50% Ethanol Extract in Acute Weight-Loaded Forced Swimming-Treated Rats
- Effect of Geraniin on Aminonucleoside Nephrosis in Rats
- Hematological Effect of Geraniin in Rat
- Effects of Geraniin on the Liver in Rats 2. Liver Drug-Metabolizing Enzymes
- Bioactive Constituent of Notopterygii Rhizoma, Falcarindiol having Antibacterial Activity against Staphylococcus aureus isolated from Patients with Atopic Dermatitis
- Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum)I. : Active Constituents Inhibiting Testosterone 5α-Reductase
- Antipruritic Effect of Cnidii Monnieri Fructus : (Fruits of Cnidium monnieri Cusson)
- Testosterone 5α-Reductase Inhibitory Active Constituents from Anemarrhenae Rhizoma
- Anti-androgenic Activity of Myricae Cortex-Isolation of Active Constituents from Bark of Myrica rubra
- Effects of Chinese Medicine on Morphological Changes in the Intestinal Villi with Age
- STRUCTURES AND ACTIVITIES OF TANNINS IN CRUDE DRUGS (3)
- Tannins and Related Polyphenols of Melastomataceous Plants. VIII.Nobotanins L, M and N, Trimeric Hydrolyzable Tannins from Tibouchina semidecandra
- Constituents of Geranium thunbergii SIEB. et ZUCC. XV. Modified Dehydroellagitannins, Geraniinic Acids B and C, and Phyllanthusiin F
- PC16 TANNINS AS RADICAL SCAVENGERS
- PA158 NEW ELLAGITANNIN OLIGOMERS FROM HETEROCENTRON ROSEUM
- Effects of Geraniin on the Liver in Rats 1. Effects of Geraniin Compared to Ellagic Acid,and Gallic Acid on Hepatic Injuries Induced by CC14,D-Galactosamine,and Thioacetamide
- Effects of geraniin on the liver in rats III : correlation between lipid accumulations and liver damage in CCl_4-treated rats
- Effect of geraniin on aminonucleoside nephrosis in rats
- Effects of geraniin on the liver in rats II : liver drug-metabolizing enzymes
- Effects of geraniin on the liver in rats I : effects of geraniin compared to ellagic acid, and gallic acid on hepatic injuries induced by CCl_4, D-galactosamine, and thioacetamide
- Hematological effect of geraniin in rat
- Effects of Chinese Medicine on Morphological Changes in the Intestinal Villi with Age
- Anti-Inflammatory Activities of Dehydrocorydaline Isolated from Corydalis Tuber
- Bioactive Constituent of Notopterygii Rhizoma, Falcarindiol having Antibacterial Activity against Staphylococcus aureus isolated from Patients with Atopic Dermatitis
- Antinociceptive and Antiinflammatory Activities of Evodiamine and Rutaecarpine
- Effects of 70% Methanol Extract from Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components on Blood Circulation
- Anti-allergic Activities of 70% Methanol Extract of Evodiae Fructus (Fruits of Evodia rutaecarpa var. bodinieri) and Its Components
- Anti-tumor Activity of Hot-water Extract of Hericium erinaceum (Bull.:Fr.) Pers. (Yamabushitake)
- Studies on Comparative Cultivation of Geranium nepalense and G. thunbergii
- Pharmacological Study on Panax ginseng C.A. MEYER V. : Effects of Red Ginseng on the Experimental Disseminated Intravascular Coagulation (4). On Ginsenoside-Rg3, Rh1 and Rh2
- Studies on Moutan Cortex (VII) : Inhibitory Effects on Histamine Release from Rat Peritoneal Mast Cells In Vitro
- Studies on Scutellariae Radix (VIII) : Anti-thrombic Actions of 70% Methanolic Extract and Various Fractions from Scutellariae Radix