Effects of 70% Methanol Extract from Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components on Blood Circulation
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概要
- 論文の詳細を見る
The effects of 70% methanol extract (EBC-ext) from Evodiae Fructus consisting of dried fruits of Evodia rutaecarpa var. bodinieri (Rutaceae) on blood circulation of rat were investigated by using various experimental models. Oral administration of EBC-ext at 50, 200 or 500 mg/kg increased the dorsal skin blood flow and elevated the rectal temperature, the blood flow of abdominal aorta and cava in normal rats and recovered the decreased blood flow and temperature caused by water-immersion stress, but had no effect on the decreased erythrocyte deformability and on the blood coagulative and fibrinolytic system. With the guidance of biological activities, alkaloidal components, evodiamine and rutaecarpine were isolated from the fruits, showing a skin blood flow, increasing effect, to which the effect of Evodiae Fructus is partially attributable.
- 日本生薬学会の論文
- 1999-02-20
著者
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Iinuma M
Gifu Pharmaceutical University
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Iinuma Munekazu
岐阜薬科大学
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Tanaka Toshiyuki
Gifu Pharmaceutical Univ.
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角谷 真
京都薬科大学
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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Kubo Michinori
Kyoto Pharmaceutical University
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Tanaka Toshiyuki
Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn
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Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Ido Yasuko
Faculty Of Pharmaceutical Sciences Kinki University
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Tanaka Toshiyuki
Gifu Pharmaceutical University
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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Yoshikawa Masato
Faculty Of Science Himeji Institute Of Technology
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YOSHIKAWA Masato
Faculty of Pharmaceutical Sciences, Kinki University
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