Antinociceptive and Antiinflammatory Activities of Evodiamine and Rutaecarpine
スポンサーリンク
概要
- 論文の詳細を見る
Evodiamine and rutaecarpin, major alkaloidal components of Evodiae Fructus (dried fruits of Evodia rutaecarpa var. hodinieri) were investigated for their antinociceptive and antiinflammatory effect. Oral administration of 30 or 100 mg/kg evodiamine significantly decreased the frequency of licking behavior in the late phase of the formalin test without affecting that of the early phase. Evodiamine inhibited not only the increases of vascular permeability induced by acetic acid and of paw edema induced by carrageenin, serotonin and bradykinin, but also the arachidonic acid-induced ear swelling. Rutaecarpine inhibited the effects of formalin test and the serotonin-, bradykinin- and arachidonic acid-induced edema. These results suggested that evodiamine and rutaecarpine possessed an antinociceptive effects mediated by antiinflammatory action, although the action mechanisms have not yet been clarified completely.
- 日本生薬学会の論文
- 1998-06-20
著者
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山崎 幹夫
千葉大学薬学部
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Iinuma M
Gifu Pharmaceutical University
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Iinuma Munekazu
岐阜薬科大学
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角谷 真
京都薬科大学
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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KO Sungkwon
Faculty of Pharmaceutical Sciences, Kinki University
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Ko Sungkwon
Faculty Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Yoshikawa Masato
Faculty Of Science Himeji Institute Of Technology
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INUMA Munekazu
Gifu Pharmaceutical University
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YOSHIKAWA Masato
Faculty of Pharmaceutical Sciences, Kinki University
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