Anti-inflammatory Activities of Methanolic Extract and Alkaloidal Components from Corydalis Tuber
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概要
- 論文の詳細を見る
A methanolic extract (CM-ext) from Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. HSU) has been screened for activity in experimental models of inflammation. CM-ext (200 or 500 mg/kg, p.o.) inhibited an increase in vascular permeability in mice induced by acetic acid, and reduced acute paw edema in rats induced by compound 48/80 or carrageenin. CM-ext suppressed the development of adjuvant-induced edema in arthritic rats. CM-ext and its alkaloidal components, dehydrocorydaline, d-glaucine and l-tetra-hydrocoptisine inhibited compound 48/80-induced histamine release from peritoneal mast cells of rats. Since these substances from C. tuber were found to be effective in both the acute and chronic phases of inflammation, the crude drug C. tuber can be considered to exert anti-inflammatory activity.
- 社団法人日本薬学会の論文
- 1994-02-15
著者
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塩本 秀己
大正製薬株式会社セルフメディケーション開発研究所
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松田 秀秋
Faculty of Pharmaceutical Sciences,Kinki University
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久保 道徳
Faculty Of Pharmaceutical Sciences Kinki University
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徳岡 清司
Faculty Of Pharmaceutical Sciences Kinki University
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Tokuoka Kiyoshi
Faculty Of Pharmaceutical Sciences Kinki University
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馬 世平
Faculty Of Pharmaceutical Sciences Kinki University
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塩本 秀己
Faculty of Pharmaceutical Sciences, Kinki University
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松田 秀秋
Faculty Of Pharmaceutical Sciences Kinki University
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