Effects of Soyasaponin on Experimental Disseminated Intravascular Coagulation. I

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概要

• 論文の詳細を見る

• The antithrombic activity of soyasaponins obtained from soybean was evaluated in the experimental model of disseminated intravascular coagulation (DIC) induced by infusion of endotoxin or thrombin in rats, as well as in vitro models (blood aggregation, conversion of fibrinogen to fibrin and activation of the fibrinolytic system). Total soyasaponin (TS) prevented the decrease of blood platelets and fibrinogen, and the increase of fibrin degradation products (FDP) in the endotoxin-induced DIC. TS also inhibited the formation of fibrin thrombi in the renal glomeruli in the thrombin-induced DIC. In vitro experiments, TS and soyasaponins, I, II, III, A_1 and A_2 inhibited the conversion of fibrinogen to fibrin. TS and soyasaponins I and II promoted activation of the fibrinolytic system in a plasminogen-containing fibrin plate.

• 公益社団法人日本薬学会の論文
• 1984-04-25

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 松田 秀秋

  近畿大学 薬学部

• 松田 秀秋

  Faculty of Pharmaceutical Sciences,Kinki University

• 久保 道徳

  Faculty Of Pharmaceutical Sciences Kinki University

• 谿 忠人

  The Research Institute of Oriental Medicine, Kinki University

• 有地 滋

  The Research Institute of Oriental Medicine, Kinki University

• 有地 滋

  The Research Institute Of Oriental Medicine Kinki University

• 有地 滋

  近畿大学東洋医学研究所

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 難液 健輔

  近畿大 薬

• 難波 健輔

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 難波 健輔

  The Research Institute of Oriental Medicine, Kinki University

• 有地 滋

  愛媛大学

• 松田 秀秋

  Faculty Of Pharmaceutical Sciences Kinki University

• 谿 忠人

  近畿大学東洋医学研究所・第1研究部門

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