Inhibitory Effect of Extracts of Muscles of Mackerel (Scomber japonicus HOUTTUYN) on Hepatic Glycogenolysis in Rats
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概要
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The effects of extracts of muscles of mackerel (Scomber japonicus; M-ext) on hepatic glycogenolysis were investigated by a rat liver perfusion method. M-ext inhibited glucagon- and cyclic adenosine monophosphate (AMP)-induced glycogenolysis but was ineffective on phenylephrine-induced glycogenolysis.The contents of hepatic glycogen and cyclic AMP, and phosphorylase and glycogen synthase activities in liver were measured after perfusion with glucagon. M-ext inhibited the increase of cyclic AMP and activation of phosphorylase.It is considered that M-ext inhibits hepatic glycogenolysis caused by glucagon through a cyclic AMP-dependent mechanism.
- 1989-02-25
著者
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久保 道徳
Faculty Of Pharmaceutical Sciences Kinki University
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松田 玲子
Faculty of Pharmaceutical Sciences, Kinki University
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松田 玲子
Faculty Of Pharmaceutical Sciences Kinki University
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