Pharmacological Study on Panax ginseng C. A. MEYER. III. : Effects of Red Ginseng on Experimental Disseminated Intravascular Coagulation. (2). : Effects of Ginsenosides on Blood Coagulative and Fibrinolytic Systems

概要

論文の詳細を見る
The activites of seven ginsenosides isolated from Red Ginseng on blood coagulative and fibrinolytic systems closely related to disseminated intravascular coagulation were investigated in in vitro models and compared with those of standard agents (aspirin, heparin and dextran sulphate).Ginsenoside-Rg_2 showed strong inhibitory activity on platelet aggregation induced by three aggregating agents (endotoxin, collagen and arachidonic acid) as compared with aspirin at a concentration of 1.0 mM. Ginsenoside-Ro inhibited the conversion of fibrinogen to fibrin induced by thrombin at concentrations of 0.1 to 1.0 mM. Ginsenoside-Ro, -Rb_1,-Rb_2,-Rc, -Re, -Rg_1 and -Rg_2 may promote the action of urokinase in the fibrinolytic system on the basis of its action on plasminogen-containing fibrin plates.
公益社団法人日本薬学会の論文
1986-03-25