Effects of Unripe Citrus hassaku Fruits Extract and Its Flavanone Glycosides on Blood Fluidity
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概要
- 論文の詳細を見る
The enhancement of blood fluidity may lead to improvements in skin problems resulting from unsmooth circulation or blood stagnation. Since a 50% ethanolic extract (CH-ext) obtained from unripe Citrus hassaku fruits may be a useful ingredient in skin-whitening cosmetics, the present study was designed to examine the effect of CH-ext on blood fluidity. CH-ext concentration-dependently inhibited in vitro collagen-induced rabbit platelet aggregation and in vitro polybrene-induced rat erythrocyte aggregation. The CH-ext showed in vitro fibrinolysis activity in fibrin plate assay. Activity-guided fractionation of the CH-ext using antiplatelet activity, inhibitory activity of erythrocyte aggregation, and fibrinolysis activity revealed that these activities of CH-ext were attributable to naringenin-7-glycoside (prunin). Successive oral administration of CH-ext to rats inhibited the lipopolysaccharide (LPS)-induced decrease of blood platelets and fibrinogen, and LPS-induced increase of fibrin degradation products (FDP) in LPS-induced disseminated intravascular coagulation (DIC) model rats. Effects of CH-ext on blood fluidity were analyzed by a micro channel array flow analyzer (MC-FAN). Preventive oral administration of CH-ext to rats showed dose-dependent reduction of the passage time of whole blood flow of the DIC model rats in comparison with that of the vehicle control rats. These results imply that CH-ext may have effects which improve effects on blood fluidity.
- 日本薬学会の論文
著者
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Itoh Kimihisa
近畿大学 薬学部薬用資源学研究室
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Itoh Kimihisa
近畿大学 農学部
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Itoh Kimihisa
Faculty Of Pharmacy Kinki University
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Itoh Kimihisa
近畿大学 薬学部
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Masuda Megumi
Faculty of Pharmacy, Kinki University
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Naruto Shunsuke
Faculty of Pharmacy, Kinki University
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Murata Kazuya
Faculty of Pharmacy, Kinki University
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Matsuda Hideaki
Faculty of Pharmacy, Kinki University
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Naruto S
School Of Pharmacy Kinki University
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Naruto Shunsuke
近畿大学 薬学部薬用資源学研究室
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Naruto Shunsuke
Faculty Of Pharmacy Kinki University
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Itoh Kimihisa
Faculty of Pharmacy, Kinki University
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