P-33 沖縄産海綿由来の新規ブロモピロールアルカロイドの構造(ポスター発表の部)

概要

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Bromopyrrole alkaloids are known to be one of the most common metabolites contained in marine sponges. During our search for bioactive substances from marine organisms, we have isolated bromopyrrole alkaloids with unique cyclic skeletons from sponges of the genus Agelas or Hymeniacidon. Recently, three new bromopyrrole alkaloids, nagelamides K, M, and N (1-3), have been isolated from an Okinawan marine sponge Agelas sp. (SS-1134). The structures and relative stereochemistry of 1〜3 were elucidated on the basis of spectroscopic data. Nagelamide K (1) is a new dimeric bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit. Nagelamide M (2) is a novel bromopyrrole alkaloid possessing an 2-amino-octahydropyrrolo[2,3-d]imidazol ring with a taurine unit, while nagelamide N (3) is a new bromopyrrole alkaloid consisting of an 2-amino-tetrahydroimidazol-4-one ring with a taurine unit and 3-(dibromopyrrole-2-carboxamido)propanoic acid moiety. Nagelamides K, M, and N (1-3) showed modest antimicrobial activity.
2008-09-01