77 海洋共生微生物より単離した新規抗腫瘍性物質の構造(口頭発表の部)

概要

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In search of new bioactive metabolites from symbiotic marine microorganisms, we have isolated two peptides from a fish-possesing fungus and three macrolides from dinoflagellates which all showed antineoplastic activity. Fellutamides A (1) and B (2), antineoplastic acylpeptides, have been isolated from the cultured fungus Penicillium fellutanum Biourge which was isolated from the stomach of the fish Apogon endekataenia Bleeker. Amphidinolide F (3) is a new antineoplastic 25-membered macrolide isolated from the cultured dinoflagellate Amphidinium sp. which was a symbiont of the Okinawan flatworm Amphiscolops magniviridis. Amphidinolides G (6) and H (7), new 27- and 26- membered macrocyclic lactones with extremely potent antineoplastic activity, have been obtained from the cultured dinoflagellate Amphidinium sp. which was a symbiont of the Okinawan flatworm Amphiscolops breviviridis. The structures of these bioactive metabolites have been elucidated from spectroscopic data including 2D NMR and chemical means.
天然有機化合物討論会の論文
1991-09-07