57 沖縄産海綿Jaspis stelliferaより単離した抗腫瘍性新規トリテルペンstelliferin A〜Fの構造(ポスター発表の部)

概要

論文の詳細を見る
During our investigations on bioactive substances from Okinawan marine organisms, we have isolated six new antineoplastic isomalabaricane-type triterpenes, named stelliferins A-F (1〜6), from Okinawan marine sponge Jaspis stellifera. The molecular formula C_<32>H_<48>O_4 of 1 was established by HREIMS. The UV spectrum of 1 indicated the presence of a trienone chromophore. The structure of 1 was deduced by a combination of ^1H-^1H COSY, HOHAHA, HMQC, and HMBC experiments as well as chemical means. The stereostructure of 1 was elucidated by NOESY spectra and modified Mosher's method. Structures of stelliferins B-F (2〜6) were determined from comparison of the spectroscopic data with those of 1. Stelliferins A-F (1〜6) exhibited potent antineoplastic activities against murine leukemia L1210 cells (IC_<50> 0.57〜2.1μg/mL) and human epidermoid carcinoma KB cells (IC_<50> 1.4〜6.0μg/mL) in vitro.
天然有機化合物討論会の論文
1991-09-07