42 培養した海産共生微細藻より単離した新規抗腫瘍性マクロライドの構造(口頭発表の部)

概要

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Recently marine micro-organisms have proved to be a new valuable source of bioactive substances, since some symbiotic micro-organisms associated with marine animals have been demonstrated to be responsible for the production of some marine natural products. Neurotoxins from symbiotic dinoflagellates are now used as essential tools in understanding the moleculalr basis of cellular excitability. During our studies on bioactive metabolites from marine organisms, we have successfully cultivated a dinoflagellate Amphidinium sp. isolated from an Okinawan flatworm Amphiscolops sp. and now isolated three novel macrolides, amphidinolide-A (1), -B (2), and -C (3) from the extract of this dinoflagellate. Their structures were elucidated on the basis of extensive spectroscopic analyses, especially by the combination of recently developed 2D NMR methods such as HMBC (^1H-detected heteronuclear multiple-bond correlation) experiment. It seems interesting that these three macrolides (1-3) with different structural and biological features were obtained from the same dinoflagellate. Amphidinolide-A, -B, and -C showed strong antineoplastic activity against L1210 murine leukemia cells with IC_<50> values of 2.4μg/mL, 0.14ng/mL, and 5.8ng/mL, respectively.
天然有機化合物討論会の論文
1987-07-25