16 沖縄産海綿より単離された生理活性物質の構造

概要

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Numerous marine natural products with biological activities have been isolated from various marine organisms. It has been expected that chemical substances possessing useful pharmacological actions will be obtained from marine organisms. We have examined pharmacological actions of 70% ethanolic extracts of various sea sponges collected at Okinawa using several isolated muscle preparations. Extracts of the sea sponge Aaptos aaptos showed an α-adrenoceptor blocking activity on the isolated rabbit aorta and a novel tricyclic heteroaromatic substance, aaptamine 1a has been isolated from the sea sponge as an active principle by monitoring the activity. In addition, the related substances, demethylaaptamine 1b and demethyloxyaaptamine 2 have been isolated from the sponge as antimicrobial substances. The orange sea sponge Agelas sp. gave extracts showing an antispasmodic activity on the isolated guinia-pig ileum and a novel sesquiterpene, agelasidine-A 7 has been isolated from the sea sponge as a main active component. Furthermore, from the brown sea sponge Agelas sp. a new bromopyrrole substance, keramadine 11 has been isolated as an antiserotonergic substance monitored by the activity on the isolated rabbit aorta. The structures of these active substances have been determined on the basis of the spectral data and chemical degradation experiments.
天然有機化合物討論会の論文
1983-09-15