Troponoidsの薬理学的研究(第3報) : 自律神経系におけるTroponoidsの薬理作用(薬理学)

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Pharmacological properties of troponoid compounds were examined with tropolone (I), 5-hydroxytropolone (II), 2-C-methoxytropone (III), 2-aminotropone (IV), 5-aminotropolone (V), 4-aminotropolone (VI), 2,5-diaminotropone (VII), 3-isopropyl-5,7-dimorpholinomethyltropolone (VIII), 5-hydroxy-3,7-dimorpholinomethyltropolone (IX), and 3,5,7-trimorpholinomethyltropolone (X). 1) I, V, and VII showed a pressor action, while VII and VIII showed a depressor action in urethaenaenesthetized rats and cats. VIII slightly supressed the pressor action induced by norepinephrine and tyramine. The mechanism of the pressor action induced by I is not clear, but it is suggested that a part of the mechanism is related to α-action. 2) V markedly potentiated the positive chronotropic action induced by isoproterenol in the heat of spinal cats. This potentiation may be due to the inhibition of cathecol-O-methyltransferase. 3) I, V, VI, and VII supressed the cardiac contractile response in isolated guinea-pig heart. 4) VII (1 mg) caused a slight vasoconstriction in the isolated perfused rabbit ear. 5) I, V, VI, and VII potentiated and IV inhibited the contraction of guinea-pig vas deferens induced by norepinephrine. 6) VII (10^<-5>g/ml) completely inhibited the contraction of vas deferens evoked by electrical stimulation of the preganglionic fiber in the guinea-pig hypogastric nerve-vas deferens. 7) V, VII, and VIII relaxed the isolated mouse illeum, while I, IV, V, VI, VII, and VIII (10^<-4>g/ml) inhibited the contraction of mouse illeum induced by acetylcholine. 8) All the test compounds did not show any muscle relaing action in phrenic nervediaphragm preparation of rats. 9) Acute toxicity in mice was also tested.
公益社団法人日本薬学会の論文
1972-01-25

Troponoidsの薬理学的研究(第3報) : 自律神経系におけるTroponoidsの薬理作用(薬理学)

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