EstroneのCholesterol-Shifting効果に対するTestosterone, Progesteroneおよび同化ステロイドFurazabolの影響

概要

論文の詳細を見る
In order to examine the interaction of sex hormones in cholesterol metabolism, testosterone, progesterone, or Furazabol was injected subcutaneously in mice and rats before three consecutive treatments with estrone and one of these steroids with estrone was injected intramuscularly for 10 days in chicks. Chloesterol and other lipids in serum and liver were determined. In mice, hypocholesteremic response to estrone was moderately inhibited by testosterone and progesterone but not significantly influenced by Furazabol. In rats, hypocholesteremia induced by estrone was inhibited by testosterone only when the animals were castrated or fed on cholesterol. Their response to estrone was not affected by progesterone but seemed to be potentiated by Furazabol. In chicks, their hypercholesteremic response to estrone was more or less weakened by testosterone and progesterone but hardly affected by Furazabol. Phospholipid and triglyceride were significantly increased in the liver of chicks treated with estrone. Phospholipid was augmented by the three hormones to the same extent but triglyceride was inhibited only by testosterone. It was concluded from these results that testosterone and progesterone tend to inhibit the cholesterol-shifting response to estrone while Furazabol has a comparatively weak effect.
公益社団法人日本薬学会の論文
1972-03-25