Amidinothiocholine系化合物の薬理作用(第2報) : N'-Methylamidinothiocholineの自律神経節興奮作用と作用部位の解明

概要

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2-Trimethylaminoethyl-1'-methylisothiuronium bromide hydrobromide (MTMA) was found to produce an increase in blood pressure and contraction of the nictitating membrane in cats. These effects were either blocked or reduced by guanethidine, hexamethonium, phentolamine, tetrodotoxin, reserpinization, or by bilateral adrenalectomy but were not appreciably affected by hemicholinium, atropine, or spinal section. Ganglion stimulating action was confirmed when the compound was injected directly to the superior cervical ganglion in cats. The stimulating action on the parasympathetic ganglia though weaker, was also observed in dogs. Hemicholinium was unable to block the contraction of the cat nictitating membrane in response to MTMA and 1,1-dimethyl-4-phenylperazinium iodide (DMPP) administered directly to the superior cervical ganglion at a time when it had blocked the contraction of the membrane elicited by preganglionic sympathetic nerve stimulation. This observation indicated that MTMA acts on the ganglion cell at the postsynaptic cholinoceptive site.
公益社団法人日本薬学会の論文
1971-08-25