筋弛緩薬およびその拮抗薬の研究(第6報) : 筋弛緩作用を有するMonoguanidino化合物の作用様式の解析

概要

論文の詳細を見る
Effect of {2-[4-(p-chlorophenyl)hexahydro-1H-azepin-1-yl] ethyl} guanidine sulfate (G-72) on several skeletal muscle praparations was examined, and following results were obtained. G-72 blocked neuromuscular transmission in sciatic-sartorius of frog, and this block was antagonized by guanidine and tetraethylammonium (TEA), but not by neostigmine. The mode of neuromuscular blocking action of G-72 was more similar to that of procaine than to those of decamethonium or d-tubocurarine. In rat diaphragm, it seemed that G-72 mainly acted on the neuromuscular junction and muscle, and its block was not antagonized by neostigmine, tetraethylammonium, decamethonium, d-tubocurarine and potassium ion. G-72 produced flaccid paralysis in hen sciatic-gastrocnemius and chicken. In some cases, G-72 and neostigmine were antagonistic, but not in other cases in hen sciatic-gastrocnemius. On frog rectus, G-72 showed dual action, i.e., competitive and non-competitive antagonism to ACh. G-72 had local anesthetic action as potent as procaine, and its action was more lasting than that of procaine as measured by intradermal weal test in guinea pigs. The concentration of G-72 required to block nerve-muscle preparation was higher in rat diaphragm than in frog sciatic-sartorius, but such difference in effective concentration was not observed with d-tubocurarine, decamethonium and procaine. From the results of experiments in hen sciatic-gastrocnemius and frog rectus, it may be concluded that G-72 would be a muscle relaxant of mixed type of type II and III (type II〜III).
公益社団法人日本薬学会の論文
1967-04-25

筋弛緩薬およびその拮抗薬の研究(第6報) : 筋弛緩作用を有するMonoguanidino化合物の作用様式の解析

スポンサーリンク

概要

著者

関連論文

スポンサーリンク