Troponoidsの薬理学的研究(第1報) : 下熱, 鎮痛および消炎作用

概要

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Pharmacological properties of 30 troponoid compounds, that have a seven-membered ring, were examined mainly for analgesic, anti-inflammatory, and hypothermic activity and the results obtained are summarized briefly below. 1) Compounds I, II, III, VII, VIII, IX, and X showed analgesic activity in mice. 2) Analgesic activity of I and VII was found to be the same as that of aminopyrine. 3) Inhibition of the central nervous system by I was less than 1/100 of that of chlorpromazine. 4) I and VII very strongly inhibited the enhancement of the capillary permeability induced by acetic acid in mice. 5) X inhibited the development of ultraviolet erythema. 6) I, II, III, VII, IX, X, and XIV showed a marked hypothermic action, and I and VII showed a more potent hypothermic action than aminopyrine.
公益社団法人日本薬学会の論文
1971-05-25