Amidinothiocholine系化合物の薬理作用(第3報) : Amidinothiotriethylcholine誘導体の自律神経系に対する影響

概要

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Pharmacological properties of 2-triethylaminoethylisothiuronium bromide hydrobromide (TEAEI), 2-triethylaminoethyl-1'-methylisothiuronium bromide hydrobromide (MTEAI), and 2-(2'-triethylaminoethylthio)imidazoline bromide hydrobromide (ETEAI), derivatives of amidinothiotriethylcholine, on autonomic nervous system were examined. These compounds showed depressor action and blocked the pressor action induced by DMPP and nicotine in rats and cats. The pressor response to adrenaline and Finkleman preparation of isolated rabbit jejunum was not blocked. Contraction of nictitating membrane in cats induced by electrical stimulation and nicotine is blocked by these compounds. TEAEI and ETEAI showed a weak negative inotropic action on the heart preparation of a guinea pig but MTEAI showed a biphasic action. Stimulating action on the isolated guinea pig ileum induced by these compounds was blocked by papaverine but not by atropine. These compounds caused a weak vasocontriction on isolated perfused rabbit ear. Contraction of vas deferens of a guinea pig induced by electrical stimulation of preganglionic fiber of hypo gastric nerve was inhibited by these compounds but contraction induced by transmural stimulation was not altered. Acute toxicity of in mice was also tested.
公益社団法人日本薬学会の論文
1971-11-25