2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第2報) : 2-(2-Diethylaminoethyl)-1'-phenylisothiuronium Bromide Hydrobromide(DEPT)の交感神経興奮作用

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Pharmacological properties, mainly sympathomimetic action, were examined on 2-(2-diethylaminoethyl)-1'-phenylisothiuronium bromide hydrobromide (DEPT), one of the 2-aminoethylisothiuronium (AET) derivatives. DEPT showed a pressor action on urethane anesthetized rat, guinea pig, rabbit, cat, and dog. DEPT caused a prolonged contraction of nictitating membrane of cat, and induced contraction of isolated vas deferens of guinea pig and seminal vesicle of rat. While DEPT showed negative inotropic and chronotropic actions on isolated heart of guinea pig, this compound showed positive inotropic and negative chronotropic actions on vagotomized open chest dog. DEPT caused a prolonged vasoconstriction on isolated perfused rabbit ear. Thus the primary mechanism of pressor action of DEPT was considered to be the vasoconstriction of peripheral vessels. Both pressor and vasoconstricting actions of DEPT were blocked by dibenzyline and potentiated by pretreatment with reserpine or guanethidine. These results suggested that the sympathomimetic action of DEPT might be classified as direct action on adrenergic α-receptors. In spinal cat, supersensitization of pressor response and of the contraction of nictitating membrane to tyramine after DEPT was observed, but those to noradrenaline was statistically nonsignificant.
社団法人日本薬学会の論文
1968-03-25