神経節遮断効果を有するAmidinothiocholine系化合物の作用様式の解明

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2-trimethylaminoethyl-1-ethylisothiuronium bromide hydrobromide (ETMA) produced a marked fall in the blood pressure of anesthetized cats. This action was not antagonized by atropine. Pressor response to adrenaline in cats and inhibitory response to electrical stimuli in Finkleman preparation of isolated rabbit jejunum were not blocked. ETMA, however, blocked blood pressure response to nicotine, to occlusion of the carotid arteries and to stimulation of the cardiac end of the cut right vagus. The contraction of the nictitating membrane in cats produced by stimulation of the preganglionic fiber, administration of DMPP (i. a.) and MTMA (i. a.) was blocked by intra-arterial injection of ETMA. The response to stimulation of the postganglionic fiber, adrenaline (i. a.) and KCl (i. a.) was not affected. These results suggest that the ETMA-induced hypotension could be related to blockade of the autonomic ganglia, presumably acting on the ganglion cell at the postsynaptic cholinoceptive site.
社団法人日本薬理学会の論文