2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第1報)
スポンサーリンク
概要
- 論文の詳細を見る
Pharmacological properties of 2-aminoethylisothiuronium (AET) derivatives were examined with 2-aminoethylisothiuronium bromide hydrobromide (I), 2-aminoethyl-N'-phenylisothiuronium bromide hydrobromide (II), 2-(2-aminoethylmercapto) imidazoline bromide hydrobromide (III), 2-aminoethyl-N', N"-dimethylisothiuronium bromide hydrobromide (IV), 2-aminoethyl-N', N"-diethylisothiuronium bromide hydrobromide (V), 2-(2-aminoethylmercapto) benzimidazoline bromide hydrobromide (VI), 2-aminoethyl-N'-α-naphtylisothiuronium bromide hydrobromide (VII), 2-dimethylaminoethylisothiuronium chloride hydrochloride (VIII), 2-diethylaminoethylisothiuronium chloride hydrochloride (IX), 2-diethylaminoethyl-N'-phenylisothiuronium bromide hydrobromide (X), and 2-(2-diethylaminoethylmercapto) imidazoline chloride hydrochloride (XI). Among these compounds, only X showed a hypertensive action on rat, cat, dog, and guinea pig, and caused a prolonged contraction of nictitating membrane of cat. Pressor actions of noradrenaline and tyramine were weakly inhibited by II, VI, VII, and X. Five mg/kg of IV and V depressed the nictitating membrane contractions of cat evoked by preganglionic stimulation of the sympathetic nerve, but did not depress the contractions evoked by postganglionic stimulation. I, VIII, and IX showed marked positive inotropic and chronotropic actions, but II, VI, VII, and X did negative inotropic and chronotropic actions on isolated heart of guinea pig. II, V, VII, and X possessed a marked muscle relaxing action on diaphragm of rat. Their activities were found to be almost the same as that of succinylcholine chloride or more. Local anesthetic, antispasmodic actions, and acute toxicity were also tested.
- 社団法人日本薬学会の論文
- 1968-02-25
著者
関連論文
- マスフラグメントグラフィーによる血中および尿中塩酸モロキシジン(ABOB)の定量
- 2-Aminoethylisothiuronium(AET)誘導体のミトコンドリア呼吸におよぼす影響
- 2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第6報) : 2-Aminoethyl-1-p-chlorophenylisothiuronium Bromide(AEPCIT)の薬理作用
- 2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第5報) : 交感神経興奮作用を有する2-(2-Diethylaminoethyl)-1-phenylisothiuronium Bromide Hydrobromide (DEPT)のTachyphylaxis現象
- 2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第4報) : 2-AminoethylisothiuroniumのN′, N″-置換体を中心とした関連化合物の酵素阻害作用
- 2-Aminoethylisothiuronium関連化合物の薬理作用(第3報) : N-DialkylおよびN-Trialkyl-2-aminoethylisothiuroniumの一般薬理作用
- 2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第2報) : 2-(2-Diethylaminoethyl)-1'-phenylisothiuronium Bromide Hydrobromide(DEPT)の交感神経興奮作用
- 2-Aminoethylisothiuronium(AET)関連化合物の薬理作用(第1報)
- Tropolone類似化合物のCatechol-O-methyltransferase阻害作用について
- 消化酵素の消炎作用の研究 : Streptomyces griseus産生ProteaseならびにBacillus amylosolvens産生α-Amylaseの抗浮腫作用