Amidinothiocholine系化合物の薬理作用(第1報)N′-MethylamidinothiocholineとN′-Ethylamidinothiocholineの薬理作用の比較

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Pharmacological properties of 2-trimethylaminoethyl-1'-methylisothiuronium bromide hydrobromide (MTMA) and 2-trimethylaminoethyl-1'-ethylisothiuronium bromide hydrobromide (ETMA), derivatives of 2-trimethylaminoethylisothiuronium bromide hydrobromide (TMAET), on autonomic nervous system were examined. MTMA gave a rise in blood pressure of the rat and cat, and caused a contraction of nictitating membrane of a cat. The pressor action and contraction of nictitating membrane were blocked by hexamethonium. On the other hand, ETMA showed depressor action and blocked the pressor action induced by acetylcholine and DMPP in rat and cat. Contraction of nictitating membrane induced by electrical stimulating and acetylcholine was blocked by ETMA. MTMA and ETMA showed a weak negative inotropic action on the heart preparation of guinea pig, but ETMA was weaker than MTMA. MTMA showed a stimulating action on the isolated guinea pig ileum. Contraction of ileum was inhibited by hexamethonium and atropine. On the other hand, ETMA had no stimulating action but blocked the contraction of ileum induced by nicotine. The contraction of vas deferens of a guinea pig induced by electrical stimulation of preganglionic fiber of hypogastric nerve was potentiated by MTMA and inhibited by ETMA. Acute toxicity in mice was also tested.
公益社団法人日本薬学会の論文
1971-06-25