Cholesterol生合成の阻害物質に関する研究(第1報) : Guanidine, Hydrazine, Tropoloneならびに2-Aminoethylisothiuronium(AET)誘導体のラット肝無細胞系におけるAcetate-1-^<14>CのCholesterolへの取込みにおよぼす影響

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The effect of guanidine, hydrazine, tropolone, and 2-aminoethylisothiuronium (AET) derivatives on the incorporation of acetate-1-^<14>C into cholesterol was examined in the rat liver homogenates. Incorporation of acetate-1-<14>C into cholesterol was inhibited to varying degrees by all of the test compounds. Among these compounds 1,1'-decamethylenediguanidine dihydrochloride, carbonyl cyanide phenylhydrazone, phenylhydrazine hydrochloride, 5-nitrosotropolone, and 2-(2-aminoethyl)-1'(p-chlorophenyl) isothiuronium bromide hydrobromide showed potent inhibitory action. The inhibitory action of these compounds was not affected by adding ATP (10^<-5>-10^<-3>M) exogenously into the incubation system. This result suggests that these compounds have sites of action other than blocking the high energy-forming system in mitochondria.
公益社団法人日本薬学会の論文
1970-02-25