Guanethidine類似化合物の薬理学的研究(第6報) : 2,3,4,5-Tetrahydro-1H-2-benzazepine-2-carboxamidine SulfateのSympathomimetic Aminesにおよぼす影響

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The effect of 2,3,4,5-tetrahydro-1H-2-benzazepine-2-carboxamidine sulfate (GQ-1) on the response of norepinephrine and tyramine was studied in spinal cats and guinea-pig vas deferens. Pretreatment with GQ-1 caused moderate supersensitivity to norepinephrine and pronounced subsensitivity to tyramine in the blood pressure and the nictitating membrane of the spinal cat ; hence the dose-response curve of norepinephrine shifted to the left and that of tyramine shifted markedly to the right. On the other hand, norepinephrine-induced contraction of the guinea-pig vas deferens was reduced by GQ-1 and not by guanethidine. It is concluded that GQ-1 has cocaine-like action in spinal cats and also adrenolytic action on the guinea-pig vas deferens.
公益社団法人日本薬学会の論文
1967-12-25