Choline作働性薬物およびAdrenaline作働性薬物のモルモット輸精管の外縦走筋の接合部電位におよぼす影響

概要

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Effects of cholinergic and adrenergic drugs on excitatory junction potential (e.j.p.) and spontaneous miniature junction potential (s.m.j.p.) of the isolated guinea-pig vas deferens have been examined by using micro-electrodes.<BR> Cholinergic drugs was not little effective on e.j.p. and s.m.j.p. and the mode of the action was different from the mode of these drugs acting on cholinergic system.<BR> Frequency of discharge of s.m.j.p. was increased by guanidine and tetraethylammonium, but was decreased by pyrogallol, and was little affected by nialamide and phentolamine. Mean amplitude of s.m.j.p. was increased by pyrogallol.<BR> These results suggeste d that discharge of s.m.j.p. did not result in only a quantum release of noradrenaline.
社団法人日本薬理学会の論文