精管および精嚢の薬物感受性に対するホルモン支配の影響(1)

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In the rat seminal vesicle, sensitivity to norepinephrine, epinephrine, acetylcholine and tyramine was increased by castration and the contractile responses showed a spontaneous phasic contraction. The sensitivity was markedly increased by estradiol treatment after castration and decreased by testosterone treatment. In the vas deferens, the contractile response to acetylcholine was weaker than that of norepinephrine, while in the 30 day castrated group it increased only the sensitivity to acetylcholine and testosterone treatment depressed only the sensitivity. Rhythmic contraction was observed on the vas deferens in the 30 day castrated rats. Testosterone treatment inhibited rhythmic response. In the 35_??_40 day castrated rats, spontaneous rhythmic contraction was also observed in the vas deferens. The frequency of the contraction was increased by application of high-K+ 10_??_40mM, and was decreased by high-Ca++ 1_??_10mM, however, the contractile response was increased. The spontaneous rhythmic contraction was not affected with TTX, atropine, cocaine, procaine, propranolol and reserpinization, however, a high dose of guanethidine, phentolamine depressed the contraction. From these observations, it is considered that the motility of the vas deferens and the seminal vesicle is controlled by gonadal hormones, and that androgen especially, exerts an inhibitory action on the motility of the genital musculature of the male rats while castration increases the sensitivity of the postsynaptic membrane.

精管および精嚢の薬物感受性に対するホルモン支配の影響(1)

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