マウス精管の神経支配に関する薬理学的ならびに電子顕微鏡的研究

概要

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Effects of cholinergic and adrenergic drugs on the transmurally stimulated mouse vas deferens were investigated as a basis for further understanding of the innervation of the mouse vas deferens. Particular attention was paid to the cholinergic mechanism in the vas deferens. Results were summarized as follows. 1) Ganglion cells are considerd to exsist in the vicinity of the vas deferens. 2) Transmural stimulation at 0.5 msec pulse duration acts on the postganglionic nerves and at 2 msec on the muscle itself. 3) Since cholinergic drugs were more effective at low than high frequency stimulation, low frequency stimulation are considerd to act on the cholinergic mechanism predominantly. 4) In the mouse vas deferens, adrenergic nerves innervate predominantly over cholinergic nerves. 5) Cholinergic and adrenergic nerves are seemed to act independently on the contractile mechanism. 6) There exsist possibilities that cholinergic nerves are resistant to atropine and therefore cholinergic receptor (J. R.) is nicotinic.
社団法人日本薬理学会の論文