遺伝性筋ジストロフィーマウスの骨格筋膜電位のPhenytoin(Diphenylhydantoin)による回復

概要

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Since phenytoin was reported to be effective in reversing membrane properties of skeletal muscle from steroid myopathy in mice, examination was made to see if phenytoin was also effective in reversing the resting membrane potentials of skeletal muscle from genetically dystrophic mice and of denervated skeletal muscle from normal mice. Experiment was made on isolated extensor digitorum longus muscle, and membrane potential was recorded with a glass electrode filled with 3 M KCl. After 25 mg/kg of phenytoin was administered i.p. for 9-11 days, the resting membrane potential of dystrophic muscle recovered to the normal level (from -67.7 to -73.2 mV), whereas those of normal (from -75.0 to -73.2 mV) and denervated muscle (from -64.0 to -62.0 mV) were not affected. These results suggested that, as regards the resting membrane potential, genetically dystrophic mouse muscle has some properties in common with steroid-induced myopathy mouse muscle rather than to surgically denervated muscle.
公益社団法人日本薬学会の論文
1978-03-25