92 沖縄産海綿Theonella sp.より単離した新規マクロライドTheonezolide Aの構造(ポスター発表の部)

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Theonezolide A (1), a novel macrolide, has been isolated from the Okinawan marine sponge Theonella sp. and the planar structure elucidated on the basis of extensive spectroscopic analyses of 1 and its four ozonolysis-products. Recent 2D NMR techniques of gradient-enhanced HMBC and HSQC-HOHAHA along with the FABMS/MS experiment were applied and proved to be quite efficient for structural study of this long aliphatic molecule. Theonezolide A (1), C_<79>H<140>N_4O_<22>S_2, is the first member of a new class of polyketide natural products consisting of two principal fatty-acid chains with various functionalities such as a sulfate ester, an oxazole, and a thiazole group, constituting a 37-membered macrocyclic lactone ring bearing a long side chain attached through an amide linkage. Compound 1 exhibited cytotoxicity against murine lymphoma L1210 and human epidermoid carcinoma KB cells in vitro with the IC_<50> values of both 0.75μg/mL.
天然有機化合物討論会の論文
1993-09-10