Radical Species in DNA Strand-Cleavage Caused by Dihydropyrazines(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
Dihydropyrazines (DHPs), which generate hydroxyl and carbon-centered radicals, cleaved DNA single-strand. It is new knowledge that DHPs were recently determined to produce 8-hydroxydeoxyguanosine. The remarkable increase in the DNA strand-cleavage activity upon the addition of Cu^<2+> suggests that the primary reactive species is carbon-centered radicals rather than the hydroxyl radical generated the initiation reaction. This proposal was in fair agreement with of the observed carbon-centered radical signal intensity, but an effect was not observed with the increase in the hydroxyl radical signal intensity.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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Takeuchi Toru
Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sci
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Matsumoto Shun-ichiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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KASHIGE Nobuhiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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YAMAGUCHI Tadatoshi
Department of Hygiene, Miyazaki Medical College
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MIAKE Fumio
Faculty of Pharmaceutical Sciences, Fukuoka University
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Yamaguchi Tokio
Faculty Of Pharmaceutical Sciences Sojo University
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Matsumoto Shuji
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Matsumoto Sayaka
Faculty Of Pharmaceutical Sciences Osaka University
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Takeuchi Toru
Department Of Environmental Medicine Faculty Of Medicine Kagoshima University
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Miake F
Faculty Of Pharmaceutical Sciences Fukuoka University
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Miake Fumio
Faculty Of Pharmaceutical Sciences Fukuoka University
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Takeda Shuso
Graduate School Of Pharmaceutical Sciences Kyushu University
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Takechi Shinji
Dept. Biochem. Miyazaki Med. Coll.
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TAKECHI Shinji
Department of Hygiene, Miyazaki Medical College
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MATSUMOTO Shigenobu
Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology
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Tadatoshi Yamaguchi
Faculty Of Hygiene Miyazaki Medical College
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Takeuchi Toru
Department Of Environmental Medicine Kagoshima University Graduate School Of Medical And Dental Scie
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Matsumoto Shigenobu
Redox Regulation Research Group Tokyo Metropolitan Institute Of Gerontology
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Kashige Nobuhiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Miake Fumio
Faculty of Pharmaceutical Science, Fukuoka University
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Kashige Nobuhiro
Faculty of Pharmaceutical Science, Fukuoka University
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Takeuchi Toru
Department of Chemistry, Faculty of Science, Shinshu University
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