Copper(II)-Catalyzed Oxidation of d-α-Tocopherol by Oxygen in Aqueous Solution
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概要
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α-Tocopherol (α-Toc) was solubilized in aqueous solutions using 13 solubilizing agents and the products of oxidation by oxygen in the presence and the absence of Cu(II) were analyzed by HPLC. In the presence of Cu(II), the oxidation was accelerated and 5-formyl-7,8-dimethyltocol and α-tocoquinone were the major oxidation products. Their yields greatly increased in the presence of Cu(II). The yields and the rates of formation of the products were dependent on the properties of solubilizing agents and other conditions as well as the presence of Cu(II) or other metal ions. It is suggested that slight changes in the structure of the solubilizing agents affect the course of the reaction.
- 公益社団法人日本薬学会の論文
- 2000-01-01
著者
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MATSUMOTO Shigenobu
Tokyo Metropolitan Institute of Gerontology
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Matsumoto Shun-ichiro
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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MATSUSHIMA Yoshikazu
Kyoritsu College of Pharmacy
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NAGATA Yoshiko
Kyoritsu College of Pharmacy
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Matsumoto Sayaka
Faculty Of Pharmaceutical Sciences Osaka University
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Matsuoka Yuji
School Of Medicine Fukuoka University
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Nagata Y
Kyoritsu College Of Pharmacy
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Matsushima Y
Kyoritsu College Of Pharmacy
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Miyamoto C
Kyoritsu College Of Pharmacy
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MIYAMOTO Chie
Kyoritsu College of Pharmacy
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