Effects of Anaerobic Exercise and Aerobic Exercise on Biomarkers of Oxidative Stress
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概要
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Objectives : In addition to having health-promoting effects, exercise of considered to induce oxidative stress. To clarify whether increased oxygen consumption during exercise induces oxidative stress, we investigated the effects of aerobic exercise and anaerobic exercise on a series of oxidative damage markers. Methods : One group of subjects performed aerobic exercise and another group performed anaerobic exercise with similar workloads, but with different levels of oxygen consumption. Blood and urine samples were collected before, immediately after, and 3, 9, and 24 h after exercise. Serum uric acid (UA) and creatine phosphokinase were evaluated. As markers of oxidative damage to lipids, proteins and DNA, we evaluated serum 4-hydroxy-2-nonenal, urinary F_2-isoprostanes, serum protein carbonyls, and leukocyte 8-hydroxydeoxyguanosine. Results : Oxygen consumption was significantly greater during aerobic exercise. Although UA level increased immediately after aerobic exercise and decreased thereafter, UA level did not change after anaerobic exercise. The two types of exercise had significantly different effects on the change in UA level. After anaerobic exercise, the levels of 8-hydroxydeoxyguanosine and 4-hydroxy-2-nonenal significantly increased at 24 h and 3 h, respectively. The levels of creatine phosphokinase and F_2-isoprostanes decreased after exercise. The two types of exercise caused no apparent significant differences in the levels of these biomarkers. Conclusion : The findings suggest that similar workloads of anaerobic exercise and aerobic exercise induce reactive oxygen species (ROS) differently : aerobic exercise seems to initially generate more ROS, whereas anaerobic exercise may induce prolonged ROS generation. Although more oxygen was consumed during aerobic exercise, the generated ROS did not induce significant oxidative damage. Oxygen consumption per se may not be the major cause of exercise-induced oxidative damage.
著者
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Ogita Futoshi
Department Of Physiological Sciences National Institute Of Fitness And Sports
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Takeuchi Toru
Department Of Environmental Medicine Faculty Of Medicine Kagoshima University
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Yamanaka Takao
Department Of Physiological Sciences National Institute Of Fitness And Sports
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Yamanaka Takao
Department Of Electrical & Electronics Engineering Sophia University
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Shi Minyi
Department Of Environmental Medicine Graduate School Of Medical And Dental Sciences Kagoshima Univer
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NAKATANI Koji
Department of Gastroenterology, Sumitomo Hospital, Osaka
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Nakatani Koji
Department Of Physiological Sciences National Institute Of Fitness And Sports
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Shi Minyi
Department Of Environmental Medicine Graduate School Of Medical And Dental Sciences Kagoshima Univer
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Takeuchi Toru
Department Of Environmental Medicine Graduate School Of Medical And Dental Sciences Kagoshima Univer
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WANG Xin
Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases at Graduate School of Medical
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Wang Xin
Division Of Antiviral Chemotherapy Center For Chronic Viral Diseases At Graduate School Of Medical A
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Takeuchi Toru
Department of Chemistry, Faculty of Science, Shinshu University
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