Chemical studies on products obtained from verdohemochrome IX.ALPHA. dimethyl ester by treatment with ammonia under air.
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概要
- 論文の詳細を見る
Verdohemochrome IXα dimethyl ester [bis(pyridine)iron(II) 5-oxaprotoporphyrin IX dimethyl ester] gave 5-azaprotohemin IX dimethyl ester (<B>2</B>) and six tripyrrin derivatives upon treatment with ammonia under air, followed by methylation. The reaction of <B>2</B> with coned HCl in acetic acid in the presence of ferrous sulfate, followed by methylation gave demetallated product, 5-azaprotoporphyrin IX dimethyl ester (<B>8</B>), accompanied by products obtained by the hydration and reduction of both or one of the vinyl groups of <B>8</B>. 8,12-Bis[2-(methoxycarbonyl)ethyl]-3,7,13-trimethyl-1-oxo-2-vinyltripyrrin-14-carbaldehyde, obtained as a major tripyrrin product by an oxidative degradation of <B>1</B>, gave a pyrromethene derivative, 3,7-bis[2-(methoxycarbonyl)ethyl]-2,8-dimethyl-l-methoxy-5-pyrromethene-9-carbaldehyde by the reaction with Tl(OAc)<SUB>3</SUB> under air. The structures of all products obtained in the present study were determined by spectral measurements.
- 公益社団法人 日本化学会の論文
著者
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Saito Setsuo
Faculty of Pharmaceutical Science,Josai University
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Tamura Norihiro
Department of Chemistry, Josai Dental University
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- Chemical studies on products obtained from verdohemochrome IX.ALPHA. dimethyl ester by treatment with ammonia under air.