Effects of Trifluoromethyl Ketones on the Motility of Proteus vulgaris(Medicinal Chemistry)
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概要
- 論文の詳細を見る
In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1-8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1- (2-benzoxazoyl) -3, 3, 3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MIC. Our results suggest the possibility of an inhibitory action of TF compounds on the proton motive forces by affecting the action of biological motor and proton efflux in the membranes, resulting in a reduction of the ratio of running and the increased number of tumbling and non-motile cells.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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Motohashi Noboru
ハンガリー
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Motohashi Noboru
Meiji Pharmaceutical University
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KAWASE Masami
Faculty of Pharmaceutical Sciences, Josai University
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Molnar Joseph
Devartment Of Medical Microbiology Faculty Of General Medicine. University Of Szeged
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Kawase Masami
Faculty Of Pharmaceutical Sciences Josai University
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WOLFART Krisztina
Devartment of Medical Microbiology, Faculty of General Medicine. University of Szeged
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MOLNAR Annamaria
Devartment of Medical Microbiology, Faculty of General Medicine. University of Szeged
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Wolfart Krisztina
Devartment Of Medical Microbiology Faculty Of General Medicine. University Of Szeged
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Molnar Annamaria
Devartment Of Medical Microbiology Faculty Of General Medicine. University Of Szeged
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