The Cyclization Reaction of Ortho-Ethynylbenzalddehyde Derivatives into Isoquinoline Derivatives
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概要
- 論文の詳細を見る
In order to elucidate the reaction mechanism of the cyclization between an ethynyl group and an imino group at the ortho-position on an aromatic ring to afford isoquinolines, reaction of 2-ethynylbenzaldehydes under various conditions was examined. It is concluded that reaction proceeds via an ionic process and the isoquinoline 4-hydrogen atom derives from the solvent. In addition, it was found taht 2-ethynylbenzaldehyde O-methyloximes underwent cycliazation in the presence of primary and secondary alcohols to give 3-substituted isoquinolines.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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Kondo Y
Meijo Univ. Nagoya Jpn
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SAKAMOTO Takao
Graduate School of Pharmaceutical Sciences, Tohoku University
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NUMATA Atsushi
Graduate School of Pharmaceutical Sciences, Tohoku University
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KONDO Yoshinori
Graduate School of Pharmaceutical Sciences, Tohoku University
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Kondo Y
Otsuka Pharmaceutical Fac. Inc. Tokushima Jpn
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Numata A
Graduate School Of Pharmaceutical Sciences Tohoku University
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Numata A
Osaka University Of Pharmaceutical Sciences
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Sakamoto Takao
Graduate School Of Pharmaceutical Sciences Tohoku University
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Sakamoto T
Second Department Of Surgery Toyama Medical And Pharmaceutical University
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Sakamoto T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Numata Atsushi
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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