The New Method for Introduction of an Allyl Group into the Angular Position of 2-(TBS-oxymethyl)-2,3,4,6,7,8-hexahydro-1-benzopyran-5-one and Its Application to Chiral Wieland-Miescher Type Compound Synthesis

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概要

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• The stereoselective introduction of an allyl group into the angular position of 2-(TBS-oxymethyl)-2,3,4,6,7,8-hexahydro-l-benzopyran-5-one was accomplished using Birch reduction and an enolate trapping reaction. It was determined that the allyl group was introduced via an unexpected conformation-flipped from the initially formed one. Two diastereomeric Wieland-Miescher type compounds, having the allyl group at the angular position, were synthesized as optically pure forms.

• 公益社団法人日本薬学会の論文
• 2005-02-01

著者

• SAKAMOTO Takao

  Graduate School of Pharmaceutical Sciences, Tohoku University

• Sakamoto Takao

  Graduate School Of Pharmaceutical Sciences Tohoku University

• Sakamoto Takao

  Graduate School Of Pharmaceutical Sciences Tohoku University:tohoku University 21st Century Coe Prog

• Hiroya K

  Graduate School Of Pharmaceutical Sciences Tohoku University

• HIROYA Kou

  Graduate School of Pharmaceutical Sciences, Tohoku University

• TAKAHASHI Taisuke

  Graduate School of Pharmaceutical Sciences, Tohoku University

• SHIMOMAE Katsunori

  Graduate School of Pharmaceutical Sciences, Tohoku University

• Shimomae Katsunori

  Graduate School Of Pharmaceutical Sciences Tohoku University

• Takahashi Taisuke

  Graduate School Of Pharmaceutical Sciences Tohoku University:tohoku University 21st Century Coe Prog

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