New μ-Opioid Receptor Agonists with Piperazine Moiety

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概要

• 論文の詳細を見る

• New μ-opioid receptor(MOR)agonists containing piperazine and homopiperazine moieties in the structures were synthesized and their affinities to and agonist potencies on MOR were evaluated. Among the synthesized compounds, 4-[4-(2-methoxyphenyl)piperazin-1-yl]-N, N-dimethyl-2, 2-diphenylbutanamide(20Aa)showed the highest affinity to the human MOR expressed in Chinese hamster ovary(CHO)-K1 cells, and the highest agonist potency on the MOR in isolated guinea-pig ileum preparation.

• 公益社団法人日本薬学会の論文
• 2001-10-01

著者

• 佐藤 真悟

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Sato S

  Tsitkuha Research Laboratories

• SAKAMOTO Takao

  Graduate School of Pharmaceutical Sciences, Tohoku University

• OKA Tetsuo

  Departmnet of Orthopedics, Asahikawa Medical College

• Oka Tetsuo

  Department Of Pharmacology School Of Medicine Tokai University

• Sato S

  Hisamitsu Pharmaceutical Co. Ltd. Ibaraki Jpn

• Sakamoto Takao

  Graduate School Of Pharmaceutical Sciences Tohoku University

• SATO Susumu

  Central Research Labs., SS Pharmaceutical Co., Ltd.

• Oka Tetsuo

  Central Research Laboratories Ssp Co. Ltd.

• KOMOTO Teruo

  Central Research Laboratories SSP Co., Ltd.

• OKADA Tomomi

  Central Research Laboratories SSP Co., Ltd.

• NIINO Yasuhiro

  Department of Pharmacology, School of Medicine, Tokai University

• Komoto Teruo

  Central Research Laboratories Ssp Co. Ltd.:graduate School Of Pharmaceutical Sciences Tohoku Univers

• OKA Tetsuo

  Department of Clinical Pharmacology, School of Medicine, Tokai University

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