α, α-gem-Difluorination of α-(Alkylthio)acetophenone Derivatives with N-Fluoropyridinium Salts
スポンサーリンク
概要
- 論文の詳細を見る
The α, α-gem-difluorination of 2', 4'-difluoro-α-(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2', 4', α, α-tetrafluoro α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem-difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).
- 公益社団法人日本薬学会の論文
- 2000-07-01
著者
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佐藤 真悟
Faculty of Pharmaceutical Sciences, Kanazawa University
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小川 道子
Department of Neurology Hamamatsu Rosai Hospital
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Sato S
Tsitkuha Research Laboratories
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Sato S
Hisamitsu Pharmaceutical Co. Ltd. Ibaraki Jpn
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Ogawa M
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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Kaneko Yoshio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kaneko Y
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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Kaneko Yasushi
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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Yoshida K
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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ETO Hiromichi
Central Research Labs., SS Pharmaceutical Co., Ltd.
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TAKEDA Sunao
Central Research Labs., SS Pharmaceutical Co., Ltd.
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TOKIZAWA Minoru
Central Research Labs., SS Pharmaceutical Co., Ltd.
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SATO Susumu
Central Research Labs., SS Pharmaceutical Co., Ltd.
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YOSHIDA Kouiti
Central Research Labs., SS Pharmaceutical Co., Ltd.
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NAMIKI Setsuo
Central Research Labs., SS Pharmaceutical Co., Ltd.
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OGAWA Masaki
Central Research Labs., SS Pharmaceutical Co., Ltd.
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Takeda Sunao
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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Eto Hiromichi
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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Namiki Setsuo
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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Tokizawa M
Central Research Labs. Ss Pharmaceutical Co. Ltd.
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