The Effects of Morphine, Naloxone and Capsaicin on C-fiber Reflex and Heat Evoked Discharge in Acute Spinal Cats
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概要
- 論文の詳細を見る
The electrophysiological effects of morphine, naloxone and capsaicin were studied on c fiber reflex and heat evoked discharge in adult spinal cats. C fiber reflex was recorded from the L_7 Ventral root at the time of superficial peroneal nerve electric stimulation. Heat evoked discharge was recorded from the L_7 ventral root at the time of hind paw heating. The drugs were injected slowly into the right cephalic vein. Our results can be summarized as follows: 1) morphine depressed the excitatory neuronal activity of capsaicin; 2) morphine followed by capsaicin was antagonized by 0.4mg/Kg of naloxone; 3) at the c fiber reflex, 2mg/Kg of morphine depressed the neuronal activity; and 4) at heat evoked discharge, 4 mg/Kg of morphine depressed the neuronal activity. These findings suggest that morphine depressed the effect of capsaicin and this effect was antagonized by naloxone. At the c fiber reflex, morphine was more sensitive than at heat evoked discharge.
- 東海大学の論文
著者
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MATSUMIYA Teruhiko
Department of Pharmacology, Tokyo Medical University
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OKA Tetsuo
Departmnet of Orthopedics, Asahikawa Medical College
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Oka T
Tokai Univ. Isehara Jpn
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Oka Tetsuo
Department Of Pharmacology School Of Medicine Tokai University
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SAWA Akio
Department of Pharmacology, School of Medicine, Tokai University
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ISHIZUKA Yoshihisa
Department of Pharmacology, School of Medicine, Tokai University
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Matsumiya Teruhiko
Department Of Pharmacology And Intractable Diseases Research Center Division Of Drug Research And De
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Sawa A
Department Of Pharmacology School Of Medicine Tokai University
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Ishizuka Yoshihisa
Department Of Pharmacology School Of Medicine Tokai University
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Matsumiya T
Department Of Pharmacology And Intractable Diseases Research Center (division Of Drug Research And D
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OKA Tetsuo
Department of Clinical Pharmacology, School of Medicine, Tokai University
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