The Effects of Morphine, Naloxone and Capsaicin on C-fiber Reflex and Heat Evoked Discharge in Acute Spinal Cats

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概要

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• The electrophysiological effects of morphine, naloxone and capsaicin were studied on c fiber reflex and heat evoked discharge in adult spinal cats. C fiber reflex was recorded from the L_7 Ventral root at the time of superficial peroneal nerve electric stimulation. Heat evoked discharge was recorded from the L_7 ventral root at the time of hind paw heating. The drugs were injected slowly into the right cephalic vein. Our results can be summarized as follows: 1) morphine depressed the excitatory neuronal activity of capsaicin; 2) morphine followed by capsaicin was antagonized by 0.4mg/Kg of naloxone; 3) at the c fiber reflex, 2mg/Kg of morphine depressed the neuronal activity; and 4) at heat evoked discharge, 4 mg/Kg of morphine depressed the neuronal activity. These findings suggest that morphine depressed the effect of capsaicin and this effect was antagonized by naloxone. At the c fiber reflex, morphine was more sensitive than at heat evoked discharge.

• 東海大学の論文

著者

• MATSUMIYA Teruhiko

  Department of Pharmacology, Tokyo Medical University

• OKA Tetsuo

  Departmnet of Orthopedics, Asahikawa Medical College

• Oka T

  Tokai Univ. Isehara Jpn

• Oka Tetsuo

  Department Of Pharmacology School Of Medicine Tokai University

• SAWA Akio

  Department of Pharmacology, School of Medicine, Tokai University

• ISHIZUKA Yoshihisa

  Department of Pharmacology, School of Medicine, Tokai University

• Matsumiya Teruhiko

  Department Of Pharmacology And Intractable Diseases Research Center Division Of Drug Research And De

• Sawa A

  Department Of Pharmacology School Of Medicine Tokai University

• Ishizuka Yoshihisa

  Department Of Pharmacology School Of Medicine Tokai University

• Matsumiya T

  Department Of Pharmacology And Intractable Diseases Research Center (division Of Drug Research And D

• OKA Tetsuo

  Department of Clinical Pharmacology, School of Medicine, Tokai University

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