The Enhancing Effects of Peptidase Inhibitors on the Antinociceptive Action of [Met5]Enkephalin-Arg6-Phe7 in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Previous in vitro studies have shown that the degradation of [Met5]enkephalin-Arg6-Phe7 during incubation with cerebral membrane preparations is largely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory effect of [Met5]enkephalin-Arg6-Phe7 administered intra-third-ventricularly on the tail-flick response was increased more than 1000-fold by the intra-third-ventricular pretreatment with three peptidase inhibitors. The antinociceptive effect produced by the [Met5]enkephalin-Arg6-Phe7 in rats pretreated with any combination of two peptidase inhibitors was significantly smaller than that in rats pretreated with three peptidase inhibitors, indicating that any residual single peptidase could inactivate significant amounts of the [Met5]enkephalin-Arg6-Phe7. The present data, together with those obtained from previous studies, clearly show that amastatin-, captopril-, and phosphoramidon-sensitive enzymes play important roles in the inactivation of endogenous opioid peptides, such as [Met5]enkephalin, [Met5]enkephalin-Arg6-Phe7, [Met5]enkephalin-Arg6-Gly7-Leu8, and dynorphin A (1-8), administered intra-third-ventricularly to rats.
- 公益社団法人 日本薬理学会の論文
著者
-
Kosaka Kenya
Department Of Clinical Pharmacology School Of Medicine Tokai University
-
Yoshikawa Masanobu
Department Of Applied Physics Faculty Of Engineering Osaka University
-
Jin Xing
Department Of Clinical Pharmacology School Of Medicine Tokai University
-
Takahashi Shigeru
Department Of Biology Osaka Kyoiku University
-
Kobayashi Hiroyuki
Department Of Anesthesiology Okayama Red Cross Hospital
-
OKA Tetsuo
Department of Clinical Pharmacology, School of Medicine, Tokai University
-
Oka Tetsuo
Department of Clinical Pharmacology, School of Medicine, Tokai University, Japan
-
Yoshikawa Masanobu
Department of Clinical Pharmacology, School of Medicine, Tokai University, Japan
-
Kosaka Kenya
Department of Clinical Pharmacology, School of Medicine, Tokai University, Japan
-
Kobayashi Hiroyuki
Department of Clinical Pharmacology, School of Medicine, Tokai University, Japan
関連論文
- Age and Sex-Dependent Alterations in Heart Rate Variability : Profiling the Characteristics of Men and Women in Their 30s
- NO吸入療法を施行した新生児遷延性肺高血圧症の神経学的予後
- サーファクタント導入後の在胎23-24週で院外出生した児の生存予測因子
- Simvastatin reduces myocardial infarct size via increased nitric oxide production in normocholesterolemic rabbits
- PJ-163 Oxytocin Treatment after Myocardial Infarction Promotes Cardiac Repair and Neovascularization through Activation of Multiple Pro-survival Signals(PJ028,Cardiovascular Pharmacology (Basic), Cost-health care system/DPC/Laws (H),Poster Session (Japane
- FRS-043 Voglibose Reduces Myocardial Infarct Size via Stimulation of GLP-1 Receptors and PI3 kinase-Akt-eNOS Pathway in Rabbits(FRS9,Novel Mechanisms of Myocardial Ischemia (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of Th
- PJ-723 The Anti-Diabetic Drug Voglibose Reduces Myocardial Infarct Size and Improves Left Ventricular Function via Production of Glucagon-like Peptide-1 in Rabbits(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 7
- PE-228 Migritol Improve Myocardial Ischemia in Type 2 Diabetic Patients with Coronary Artery Disease(Nuclear cardiology(04)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-182 Oxytocin reduces myocardial infarct size and improves left ventricular function and remodeling through activation of Akt, VEGF, BCI-2 and Angiogenesis(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
- OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
- OJ-254 Erythropoietin Drug Delivery System protects the heart against myocardial infarction through activation of Akt and angiogenesis(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-128 Pioglitazone, an Anti-Diabetic Drug, Reduces Myocardial Infarct Size via Stimulating Peroxisome Proliferator Activated Receptor-γ (PPARγ) in Rabbits Model of Myocardial Infarction(Myocardial ischemia/reperfusion, basic/clinical-1, The 71st Annual S
- 新生児頭蓋内病変における血清S100蛋白Bの動態
- 超低出生体重児の出生時ヘモグロビン値の輸血と新生児期の適応にあたえる効果
- Prediction of transfusions in extremely low-birthweight infants in the erythropoietin era
- Successful recombinant erythropoietin therapy for a developing anemic newborn with hereditary spherocytosis
- Failure of stent implantation in an infant with congenital tracheal stenosis
- Spontaneous labor increases nitric oxide synthesis during the early neonatal period
- Using polymerase chain reaction for rapid sex-determination of a case of sirenomelia
- A Case Report of Lethal Multiple Pterygium Syndrome
- PE-187 Sustained Release of Granulocyte Colony-Stimulating Factor Using Biodegradable Gelatin Hydrogel Improves Limb Ischemia(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Me
- OJ-314 Drug Delivery System Using Erythropoietin Gelatin Hydrogel Sheet Decreases Myocardial Infarct Size and Improves Left Ventricular Function and Remodeling(Growth factor/Cytokine-1 (H) OJ53,Oral Presentation (Japanese),The 70th Anniversary Annual Scie
- I-28 THE CLINICAL SIGNIFICANCE OF GROWTH FACTORS WITH VESICO-URETERAL REFLUX IN CHILDREN
- PJ-440 Ginsenoside Rg1 Reduces Myocardial Infarct Size via Activation of Protein Kinase C and Production of Nitric Oxide in Rabbits(Acute myocardial infarction, basic-4 (IHD) PJ74,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
- PJ-343 Post-infarction Treatment with Ginsenoside Rg1 Improves Cardiac Function and Left Ventricular Remodeling Through Enhancement of Intrinsic G-CSF(Cardiovascular pharmacology, basic/clinical-4 (H) PJ58,Poster Session (Japanese),The 70th Anniversary An
- Acarbose, an α-glucosidase Inhibitor, Reduces Myocardial Infarct Size in Rabbits Involving the Opening of Mitochondrial KATP Channels(Diabetes/Obesity 8 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Botryoid Wilms' tumor : a report of two cases
- Superconductivity in the Pb_2Sr_La_xCu_2O_z System
- Single High-T_c Phase Region of the Bi-Pb-Sr-Ca-Cu-O System
- Prognostic Significance of FLT3 Internal Tandem Duplication and NPM1 Mutations in Acute Myeloid Leukemia in an Unselected Patient Population
- Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland
- P-082A Primary reduction and spontaneous sutureless closure of Gastroschisis using a wound retractor(International Session III, the 44th Annual Meeting of Japanese Society of Pediatric Surgeons)
- P-081A Application of a ring retractor system in pediatric general and urogenital surgery(International Session III, the 44th Annual Meeting of Japanese Society of Pediatric Surgeons)
- IS-7 Intussusception reduction by pediatric surgical team : How to improve safety and outcome(International Session2)
- Recipient non-hematopoietic bone marrow cells in the intestinal graft after fetal small intestinal transplantation
- IS-017 Prenatal detection of pyriform sinus cyst : A case report
- IS-001 Methicillin-resistant staphylococcus aureus (MRSA) enteritis in neonates : A new clinical entity
- IS-021 Recipient non-hematopoietic bone marrow cells in the intestinal graft after fetal small intestinal transplantation
- Modification of Post-Myocardial Infarction Granulocyte-Colony Stimulating Factor Therapy With Myelosuppressives
- Cysteinyl Leukotriene Receptor Antagonists Inhibit Tumor Metastasis by Inhibiting Capillary Permeability
- 2 Monthly Medication Cost of Out-Patients at High Risk for Myocardial Infarction or Stroke : Results from J-TRACE study(Symposium 17 (SY-17) (H) Comprehensive Economics in Clinical Cardiology : Current Status and Problems,Special Program,The 72nd Annual S
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- Microwave Power Emission from a Beam-Plasma System
- Correlation between High-Power Broadband Microwave Radiation and Strong Langmuir Turbulence in an Intense Relativistic Electron Beam-Plasma System
- Spectroscopic Measurements of Intense Relativistic Electron Beam Driven Turbulence
- Spectroscopic System for Measurememts of Turbulent Electric Fields Originating from Intense Relativistic Electron Beam-Plasma Interactions
- IS-6 Efficacy of Protocolized Management for Congenital Diaphragmatic Hernia : A Review of 100 cases(International Session2)
- IS-4 Surgical Treatment and Outcome of the Mega-hydronephrosis due to Pelviureteric Junction Stenosis(International Session1)
- IS-8 Prospective Analysis of Primary Modified Georgeson's Laparoscopy-assisted Endorectal Pull-Through
- Posterior urethral diverticulum after laparoscopic-assisted repair of high-type anorectal malformation in a male patient : surgical treatment and prevention
- Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats
- Roux-en-Y hepaticojejunostomy or hepaticoduodenostomy for biliary reconstruction during the surgical treatment of choledochal cyst : which is better?
- P-114 Lung injury and diaphragmatic hernia caused by multiple exostoses : A Case report
- IS-17 Posterior urethral diverticula after laparoscopy-assisted repair of high anorectal malformations in male patients : Surgical treatment and prevention(International Session III)
- Intracorporeal electrohydraulic lithotripsy for intrahepatic bile duct stone formation after choledochal cyst excision
- Massive debris in the intrahepatic bile ducts in choledochal cyst : possible cause of postoperative stone formation
- Suspicion of prenatal pyriform sinus cyst and fistula : a case report
- P-103 Intracorporeal electro hydraulic lithotripsy for intrahepatic bile duct stones after choledochal cyst excision
- P-079A Magnetic Resonance Angiography Versus Endoscopy for the Assessment of Esophagogastric Varices in Biliary Atresia(International Session III, the 44th Annual Meeting of Japanese Society of Pediatric Surgeons)
- P-118 Hepatico-jejunostomy or hepatico-duodenostomy for biliary reconstruction during surgical treatment of choledochal cyst; Which is Better?
- Temperature Dependence of the Crystal Growth Rate of Potassium Sulfate at Low Temperature
- P-098 Sigmoidocolocystoplasty for augmentation of iatrogenic small capacity bladder caused by direct injury during inguinal hernia repair : Longterm follow-up
- Calibration of Time- and Space-Resolving Vacuum Ultraviolet Spectrograph for Plasma Diagnostics in the Tandem Mirror GAMMA 10
- Dielectric Dispersion and Twin Structure in Hexagonal Barium Titanate
- Physiologic significance of nitric oxide and endothelin-1 in circulatory adaptation
- Postinfarction Treatment With Edaravone, a Free Radical Scavenger, Reduces Myocardial Infarct Size, Improves Cardiac Function and Remodeling in Rabbits(Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese C
- IS-019 INCREASED LEVELS OF CIRCULATING ADHESION MOLECULES IN NEONATES WITH CONGENITAL DIAPHRAGMATIC HERNIA COMPLICATED BY PERSISTENT PULMONARY HYPERTENSION
- Great Increase in Antinociceptive Potency of [Leu^5]Enkephalin After Peptidase Inhibition
- The Enhancing Effects of Peptidase Inhibitors on the Antinociceptive Action of [Met^5]Enkephalin-Arg^6-Phe^7 in Rats
- Design and Synthesis of Peptides Passing through the Blood-Brain Barrier
- Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin
- Raltitrexed, a Novel Folate-Based Thymidylate Synthase Inhibitor, for the Treatment of Acute Leukemia: Is This Drug Active Against Acute Myelogenous Leukemia?
- Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance
- Cytotoxicity of Trimetrexate against Antifolate-resistant Human T-Cell Leukemia Cell Lines Developed in Oxidized or Reduced Folate
- Biological Activity and Intracellular Metabolism of ZD1694 in Human Leukemia Cell Lines with Different Resistance Mechanisms to Antifolate Drugs
- Improvement of SiO_2/4H-SiC Interface Using High-Temperature Hydrogen Annealing at Low Pressure and Vacuum Annealing
- Improvement of SiO2/4H-SiC Interface by Using High Temperature Hydrogen Annealing at 1000℃
- Absolute Calibration of Space- and TIme-Resolving Flat-Field Vacuum Ultraviolet Spectrograph for Plasma Diagnostics
- Effect of Nd422 Addition on Jc in Nd123 Melt-Textured Bulk Superconductor
- Pulsed Field Magnetization of Melt-Processed Y-Ba-Cu-O Bulk Superconductor with No Weak Links
- High-Temperature Superconducting Motor Using Y-Ba-Cu-O Bulk Magnets
- Growth Mode Transition in GaAs/Gap(001)
- Surface Stoichiometry and Reconstruction of GaP(001)
- Growth Process in Initial Stage of GaAs/GaP (001) by Molecular Beam Epitaxy
- Time Course of Changes in μ-Opioid Receptor mRNA Levels in the Periaqueductal Gray of Rat Brain by a Single or Repeated Injections of Antisense Oligodeoxynucleotides
- SYMPATHETIC BLOCKADE AFTER STELLATE GANGLION BLOCK : A CONTINUOUS RECORDING USING SKIN POTENTIAL ACTIVITY
- Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase
- Tunica Interna Endothelial Cell Kinase Expression and Hematopoietic and Angiogenic Potentials in Cord Blood CD34^+ Cells
- The serine racemase mRNA is expressed in both neurons and glial cells of the rat retina
- The serine racemase mRNA is predominantly expressed in rat brain neurons
- Purification and Some Properties of Inulin Fructotransferase (Depolymerizing) from Arthrobacter ilicis(Biological Chemistry)
- Multiple approaches to clarify the mechanisms underlying plant gall morphogenesis and plant cell regulation by galling insects
- Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase
- Raman Spectra of NH_4-TCNQ-I and -II
- Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine
- The Antinociceptive Effects of Midazolam on Three Different Types of Nociception in Mice
- Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland
- Analysis of Non-Gaussian Speckle by Nakagami m-Distribution
- The Enhancing Effects of Peptidase Inhibitors on the Antinociceptive Action of [Met5]Enkephalin-Arg6-Phe7 in Rats
- Purification and Properties of Eclosion Hormone of the Silkworm, Bombyx mori