Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
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概要
- 論文の詳細を見る
Effect of KW−5092({1−[2−[[[5−(piperidinomethyl)−2−furanyl]methyl]amino]ethyl]−2−imidazolidinylidene}propanedinitrile fumarate)on intestinal motility and release of endogenous acetylcholine(ACh)were measured simultaneously in the small intestine of anesthetized dog using the in vivo microdialysis method.Intraarterial and intravenous administrations of KW−5092 accelerated the intestinal motility and increased dialysate ACh concentrations.These KW−5092−induced responses paralleled the increase in blood concentration of KW−5092.Thus, the acceleration of intestinal motility by KW−5092 was found in vivo to be associated with an increase in ACh release from the intestinal cholinergic neurons.
- 社団法人 日本薬理学会の論文
- 2000-06-01
著者
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Kanematsu Takashi
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Kanematsu T
Division Of Surgery Department Of Translational Medical Sciences Nagasaki University Graduate School
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Kobayashi Hiroyuki
Department Of Pediatric Surgery Juntendo Univ
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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YAMAZAKI Akira
Department of Physics, Aoyama-Gakuin University
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Kanematsu Takashi
長崎大学 医歯薬総研究外科学
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Kanematsu Takashi
Div. Of Surgery Dep. Of Translational Medical Sciences Nagasaki Univ. Graduate School Of Biomedical
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KISHIBAYASHI Nobuyuki
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Kanematsu Takashi
Department Of Surgery Ii Nagasaki University School Of Medicine
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Kanematsu Takashi
Department Of Surgery Graduate School Of Biomedical Sciences Nagasaki University
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FURUICHI Akira
Department of Surgery II, Nagasaki University School of Medicine
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MAKIMOTO Noriaki
Department of Surgery II, Nagasaki University School of Medicine
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TANIYAMA Kohtaro
Departments of Pharmacology
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Taniyama K
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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Taniyama Kohtaro
Division Of Pharmacology Department Of Translational Medical Sciences Nagasaki University Graduate S
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Taniyama Kohtaro
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Ohmori Kenji
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Kobayashi Hiroyuki
Department Of Applied Chemistry Saitama University
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Takemura Keiko
Department Of Pharmacology Nagasaki University School Of Medicine
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Furuichi Akira
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Makimoto Noriaki
Division Of Surgery Department Of Translational Medical Sciences Nagasaki University Graduate School
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Kanematsu Takashi
Department Of Dental Pharmacology Division Of Integrated Medical Science Graduate School Of Biomedic
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Kanematsu Takashi
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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Kishibayashi Nobuyuki
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kishibayashi Nobuyuki
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Yamazaki Akira
Department Of Molecular Pharmacology Kitasato University Graduate School Of Medicinal Graduate Cours
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Yamazaki Akira
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Kobayashi Hiroyuki
Department Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Kobayashi Hiroyuki
Department Of Anesthesiology Okayama Red Cross Hospital
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Taniyama Kohtaro
Department of Pharmacology 2, Nagasaki University School of Medicine
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