Re-evaluation of lipiodolized transarterial chemoembolization therapy for intrahepatic recurrence of hepatocellular carcinoma after curative liver resection.
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概要
- 論文の詳細を見る
The original publication is available at www.springerlink.comBACKGROUND/PURPOSE: While lipiodolized transarterial chemoembolization (lip-TACE) is effective for treating unresectable hepatocellular carcinoma (HCC), its effect for treating recurrent HCC after curative liver resection needs to be clarified. METHODS: Of 163 patients who had undergone curative liver resection between 1992 and December 2003, 65 patients (39.8%) had recurrent HCC in the liver without extrahepatic recurrence and were indicated for lip-TACE. The overall survival rate after lip-TACE was calculated, and its correlation with factors such as the histology of the primary HCC and background noncancerous tissue were analyzed. RESULTS: The overall survival rates after lip-TACE after the detection of the first recurrent HCC were 82.6%, 44.5%, and 24.8% at 1, 3, and 5 years, respectively. The factors affecting patient survival after lip-TACE were microscopic portal venous involvement of HCC at liver resection, grade of inflammation in the noncancerous liver parenchyma, and recurrence within 1 year after the initial liver resection. Multivariate analysis showed that the period between the resection and first recurrence had the highest hazard ratio. CONCLUSIONS: Lip-TACE is a reasonable procedure for treating recurrent HCC in selected patients who are not eligible for hepatic re-resection. When HCC recurred within 1 year from the primary liver resection, the effect of lip-TACE on patient survival was limited.
- Springer Japanの論文
- 2008-11-01
著者
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Kanematsu Takashi
長崎大学 医歯薬学総合研究科外科
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Kanematsu Takashi
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Eguchi Susumu
長崎大学 医歯薬学総合研究科外科
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Eguchi Susumu
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Eguchi S
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Hidaka Masaaki
長崎大学 医歯薬学総合研究科外科
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Hidaka Masaaki
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Hidaka Masaaki
Departments Of Surgery Nagasaki Prefectural Shimabara Onsen Hospital
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Takatsuki Mitsuhisa
長崎大学 医歯薬学総合研究科外科
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Moriuchi Takuji
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Takatsuki Mitsuhisa
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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Matsuo Shigetoshi
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Matsuzaki Toshihisa
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Eguchi Susumu
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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Tajima Yoshitsugu
国立病院機構佐賀病院 外科
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Tajima Yoshitsugu
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Eguchi S
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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HAMASAKI Koji
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
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MATSUMOTO SHIGEHIRO
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
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SAKAMOTO ICHIRO
Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences
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Tajima Y
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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Kanematsu Takashi
長崎大学 医歯薬総研究外科学
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Eguchi Susumu
Departments Of Surgery Nagasaki Prefectural Shimabara Onsen Hospital
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Hamasaki Koji
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Kanematsu Takashi
Div. Of Surgery Dep. Of Translational Medical Sciences Nagasaki Univ. Graduate School Of Biomedical
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Hamasaki Koji
Department Of Bioengineering Faculty Of Engineering Soka University Tangi
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Sakamoto Ichiro
Department Of Radiology Nagasaki University Graduate School Of Biomedical Sciences
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Takatsuki Mitsuhisa
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Sakamoto Ichiro
Department Of Cardiovascular Surgery Nagasaki University
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Eguchi Susumu
Department Of Surgery Ii Nagasaki University School Of Medicine
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Kanematsu Takashi
Department Of Dental Pharmacology Division Of Integrated Medical Science Graduate School Of Biomedic
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Kanematsu Takashi
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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Matsumoto Shigehiro
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Matsuo Shigetoshi
Department Of Surgery Nagasaki Prefecture Shimabara Hospital
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Tajima Yoshitsugu
長崎大学 大学院医歯薬学総合研究科外科
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Matsumoto Shigehiro
Department Of Gastroenterology And Hepatology Graduate School Of Biomedical Sciences Nagasaki University
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Tajima Yoshitsugu
Department Of Surgery Nagasaki Municipal Hospital
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Takatsuki Mitsuhisa
Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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