Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation.
スポンサーリンク
概要
- 論文の詳細を見る
Aim: To identify the problems of pegylated interferon (PEG IFN) with ribavirin therapy against hepatitis C virus (HCV) reinfection in living donor liver transplantation (LDLT) patients. HCV kinetics during the PEG IFN with ribavirin therapy were analyzed in LDLT patients, as well as in chronic hepatitis C (CHC) patients. Methods: The study included 80 consecutive HCV infected patients undergoing PEG IFN with ribavirin therapy (64 CHC and 16 LDLT patients) who attended the Nagasaki University Hospital for an initial visit between January 2005 and December 2007. Results: The sustained viral response (VR) rate of the CHC group (80%) was superior to the LDLT group (22%). The viral disappearance rate of the CHC group was also superior to the LDLT group, regardless of the HCV serotype. The HCV core antigen (cAg) titer under treatment in the LDLT group was more than that of the CHC group from day 0 to week 12. The HCV cAg decrease rate of the LDLT group on the first day of treatment was less than that of the CHC group. Conclusion: The HCV infection of a transplanted liver is more refractory to treatment than a non-transplanted liver. The low reduction HCV cAg rate on day 1 is one of the problems of the combination therapy.
- 2009-09-01
著者
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江口 勝美
長崎大学医学部附属病院第一内科学教室
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Kanematsu Takashi
長崎大学 医歯薬学総合研究科外科
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Kanematsu Takashi
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Eguchi Susumu
長崎大学 医歯薬学総合研究科外科
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Eguchi Susumu
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Eguchi S
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Miyaaki Hisamitsu
長崎大学 医歯薬学総合研究科臨床薬学
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Miyaaki Hisamitsu
Department Of Gastroenterology And Hepatology Nagasaki University Graduate School Of Biomedical Scie
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Miyaaki Hisamitsu
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Miyaaki Hisamitsu
Department Of Pathology And Research Center Of Innovative Cancer Therapy Of The 21st Century Coe Pro
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Ichikawa Tatsuki
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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Ichikawa Tatsuki
長崎大学 医歯薬学総合研究科外科
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Ichikawa Tatsuki
長崎大学 医歯薬学総合研究科臨床薬学
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Ichikawa Tatsuki
Department Of Gastroenterology And Hepatology Nagasaki University Graduate School Of Biomedical Scie
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Nakao Kazuhiko
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Nakao Kazuhiko
長崎大学 医歯薬学総合研究科臨床薬学
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Takatsuki Mitsuhisa
長崎大学 医歯薬学総合研究科外科
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Moriuchi Takuji
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Takatsuki Mitsuhisa
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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江口 勝美
長崎大学第一内科
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江口 勝美
聖マリアンナ医科大学附属難病治療研究センター ゲノム医科学 研究部門
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江口 勝美
長崎大学大学院医歯薬学総合研究科病態解析・制御学講座
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江口 勝美
長崎県済生会病院 内科
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Matsuo Shigetoshi
長崎県立島原病院 外科
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Matsuo Shigetoshi
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Eguchi Katsumi
First Department Of Internal Medicine Nagasaki University Hospital Of Medicine And Dentistry Graduat
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Eguchi Katsumi
長崎大学 医歯薬学総合研究科臨床薬学
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Matsuzaki Toshihisa
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Eguchi Susumu
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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Miyaaki Hisamitsu
Nagasaki Univ. Nagasaki Jpn
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ICHIKAWA Tatsuki
The First Department of Internal Medicine, Nagasaki University School of Medicine
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TAKESHITA Shigeyuki
The First Department of Internal Medicine, Nagasaki University School of Medicine
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SHIBATA Hidetaka
The First Department of Internal Medicine, Nagasaki University School of Medicine
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OZAWA Eisuke
The First Department of Internal Medicine, Nagasaki University School of Medicine
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AKIYAMA Motohisa
The First Department of Internal Medicine, Nagasaki University School of Medicine
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MIUMA Satoshi
The First Department of Internal Medicine, Nagasaki University School of Medicine
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EGUCHI Katsumi
The First Department of Internal Medicine, Nagasaki University School of Medicine
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FUJIMITO Masumi
The First Department of Internal Medicine, Graduate School of Biomedical Sciences
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Shibata Hidetaka
Nagasaki Univ. Nagasaki Jpn
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Shibata Hidetaka
長崎大学 医歯薬学総合研究科臨床薬学
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Shibata Hidetaka
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Akiyama Motohisa
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Akiyama Motohisa
長崎大学 医学部第一内科
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Miuma Satoshi
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Miuma Satoshi
長崎大学 医学部第一内科
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Takeshita Shigeyuki
Nagasaki Univ. Nagasaki Jpn
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Takeshita Shigeyuki
長崎大学 医歯薬学総合研究科臨床薬学
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Takeshita Shigeyuki
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Ozawa Eisuke
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Eguchi S
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Shibata Hidetaka
長崎大学 医学部第一内科
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Ichikawa T
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Ichikawa Tatsuki
長崎大学 医学部第一内科
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Ichikawa Tatsuki
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Takeshita Shigeyuki
長崎大学 医学部第一内科
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Eguchi Katsumi
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Fujimoto Masumi
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Nakao Kazuhiko
長崎大学 医学部第一内科
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江口 勝美
長崎大学附属病院第一内科
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Kanematsu Takashi
長崎大学 医歯薬総研究外科学
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Eguchi Susumu
Departments Of Surgery Nagasaki Prefectural Shimabara Onsen Hospital
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Kanematsu Takashi
Div. Of Surgery Dep. Of Translational Medical Sciences Nagasaki Univ. Graduate School Of Biomedical
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Kanematsu Takashi
Department Of Surgery Graduate School Of Biomedical Sciences Nagasaki University
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Ichikawa Tatsuki
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Takatsuki Mitsuhisa
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Nakata Keisuke
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Eguchi Susumu
Department Of Surgery Ii Nagasaki University School Of Medicine
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Kanematsu Takashi
Department Of Dental Pharmacology Division Of Integrated Medical Science Graduate School Of Biomedic
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Kanematsu Takashi
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
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江口 勝美
Unit Of Translational Medicine Department Of Immunology And Rheumatology Graduate School Of Biomedic
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Eguchi Katsumi
First Department Of Internal Medicine Nagasaki University Hospital Of Medicine And Dentistry Graduate School Of Biomedical Sciences Nagasaki University
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Takatsuki Mitsuhisa
Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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