The Significance of Enzyme Immunoassay for the Assessment of Hepatitis B Virus Core-Related Antigen following Liver Transplantation
スポンサーリンク
概要
- 論文の詳細を見る
Purpose Recently, a new enzyme immunoassay for the detection of hepatitis B virus (HBV) core-related antigen (HBcrAg) has been reported. In this study, we proposed to account for feasibility of HBcrAg assay, and discuss the dynamics of HBV seen in patients following HBV-related living donor liver transplantation (LDLT). Methods and results This study involved 12 patients; 11 patients had positive serum HBcrAg, and 6 patients had negative HBV-DNA. In the post-operation period, all cases were negative for HBV-DNA and HBsAg in sera under prophylaxis therapy. At post-operation, 5 of the 12 had positive serum HBcrAg, and at stable state, 6 had positive serum HBcrAg postoperatively. The mean levels of HBcrAg following LDLT were significantly lower than those seen in the preoperative-operation stage. Conclusion This enzyme immunoassay is a readily utilizable marker of HBV replication in the post transplantation stage. Furthermore, the evaluation of HBV activity by HBcrAg assay must be studied to determine the appropriate prophylaxis for controlling replication of HBV following LDLT.
- 日本内科学会,The Japanese Society of Internal Medicineの論文
著者
-
Yatsuhashi Hiroshi
Clinical Research Center, National Nagasaki Medical Center
-
Kanematsu Takashi
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
-
Eguchi Susumu
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
-
Miyaaki Hisamitsu
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
-
Nakao Kazuhiko
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
-
Nakao Kazuhiko
長崎大学 医歯薬学総合研究科臨床薬学
-
Takatsuki Mitsuhisa
Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica
-
ICHIKAWA Tatsuki
The First Department of Internal Medicine, Nagasaki University School of Medicine
-
SHIBATA Hidetaka
The First Department of Internal Medicine, Nagasaki University School of Medicine
-
EGUCHI Katsumi
The First Department of Internal Medicine, Nagasaki University School of Medicine
-
Shibata Hidetaka
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
-
FUJIMOTO Masumi
The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki Universi
-
Eguchi Katsumi
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
-
Fujimoto Masumi
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
-
Nagaoka Shinya
Clinical Research Center, National Nagasaki Medical Center
-
Ichikawa Tatsuki
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
-
Takatsuki Mitsuhisa
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
-
Yatsuhashi Hiroshi
Clinical Research Center National Hospital Organization (nho) Nagasaki Medical Center
-
Eguchi Susumu
Department Of Surgery Ii Nagasaki University School Of Medicine
-
Kanematsu Takashi
Department Of Dental Pharmacology Division Of Integrated Medical Science Graduate School Of Biomedic
-
Nagaoka Shinya
Clinical Research Center National Nagasaki Medical Center
-
Eguchi Susumu
Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University
-
SHIBATA Hidetaka
The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
-
FUJIMOTO Masumi
The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
-
Nakao Kazuhiko
The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
-
Kanematsu Takashi
Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University
-
Takatsuki Mitsuhisa
Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
-
Takatsuki Mitsuhisa
Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University
関連論文
- Semi-quantitative discrimination of HBV mutants using allele-specific oligonucleotide hybridization with Handy Bio-Strand(METHODS)
- Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation.
- Semi-quantitative discrimination of HBV mutants using allele-specific oligonucleotide hybridization with Handy Bio-Strand
- Torsion of the gallbladder in a 3-year-old infant
- Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC) : The HLA-DRB1 polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC
- Clinical features of 89 patients with autoimmune hepatitis in Nagasaki Prefecture, Japan
- Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation.
- Predictive value of suppressor of cytokine signal 3 (SOCS3) in the outcome of interferon therapy in chronic hepatitis C
- Interferon-alpha-induced mTOR activation is an anti-hepatitis C virus signal via the phosphatidylinositol 3-kinase-Akt-independent pathway.
- Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver.
- A secure taping technique for a liver hanging maneuver using a surgical probe.
- Re-evaluation of lipiodolized transarterial chemoembolization therapy for intrahepatic recurrence of hepatocellular carcinoma after curative liver resection.
- Compressive stenosis of the inferior vena cava due to localized ascites after living-donor liver transplantation.
- Evolution of living donor liver transplantation over 10 years: experience of a single center.
- Inactivation of porcine endogenous retrovirus by human serum as a function of complement activated through the classical pathway
- A new suppressive agent against interleukin-1β and tumor necrosis factor-α enhances liver regeneration after partial hepatectomy in rats
- An Unusual Perforation of the Colon : Report of Two Cases
- Impaction of a Shrapnel Splinter in the Common Bile Duct After Migrating from the Right Thoracic Cavity : Report of a Case
- Hepatic expression and serum levels of thrombomodulin reflect the extent of liver injury in rats with fulminant hepatic failure and extensive hepatectomy
- Successful Repeated Transcatheter Arterial Embolization (TAE) for Multiple Liver Metastases from Breast Cancer
- A Case of Ductal Dysplasia of the Pancreas A Possible Prerequisite for Pancreatic Cancer
- The Fas/Fas-ligand system functions in hepatocytes in the early stage of fulminant hepatic failure in rats
- Presence of GABA_B Receptors Forming Heterodimers With GABA_ and GABA_ Subunits in Human Lower Esophageal Sphincter
- The Significance of Enzyme Immunoassay for the Assessment of Hepatitis B Virus Core-Related Antigen following Liver Transplantation
- Intraoperative pancreatography and gastric-wall-covering method for the prevention of pancreatic leakage after enucleation of insulinoma in the pancreas
- Common Fragile Genes and Digestive Tract Cancers
- Hepatolithiasis and intrahepatic cholangiocarcinoma : carcinogenesis based on molecular mechanisms
- Parapapillary choledochoduodenal fistula associated with cholangiocarcinoma
- Genetic Alterations in Gallbladder Carcinoma
- Role of Hypermethylation on Carcinogenesis in the Pancreas
- Primary hepatic carcinoid tumor
- Small non-functioning endocrine tumor of pancreas : Comparison with solid cystic tumor
- Treatment of bleeding stomal varices by balloon-occluded retrograde transvenous obliteration
- Changes in Colonic Motility in Dogs After a Resection of the Inferior Mesenteric Ganglion and Plexus
- Autoimmune hepatitis in a patient with systemic lupus erythematosus : a case report
- Possible Protection of Sinusoidal Endothelial Cells by Endothelin B Receptor During Hepatic Warm Ischemia-Reperfusion
- Urinary Iodine Levels and Thyroid Diseases in Children; Comparison between Nagasaki and Chernobyl
- Human intrahepatic biliary epithelial cell as possible modulator of hepatic regeneration : Potential role of biliary epithelial cell for hepatic remodeling in vivo
- Ruptured Aneurysm of the Visceral Artery : Report of Two Cases
- Increasing hepatitis C virus-associated hepatocellular carcinoma mortality and aging : Long term trends in Japan
- Nonalcoholic Steatohepatitis with Improved Hepatic Fibrosis after Weight Reduction
- Association Between Nonalcoholic Fatty Liver, Markers of Obesity, and Serum Leptin Level in Young Adults
- Amyloid a Protein Amyloidosis in a Patient with Plasma Cell Dyscrasia
- Geranylgeraniol, an Intermediate Product in Mevalonate Pathway, Induces Apoptotic Cell Death in Human Hepatoma Cells : Death Receptor-independent Activation of Caspase-8 with Down-regulation of Bcl-xL Expression
- Clinical Features of Fulminant Hepatitis in Nagasaki Prefecture, Japan
- Attenuation of Responsiveness to Interferon-α Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus
- Spontaneous loss of hepatitis B surface antigen in chronic carriers, based on a long-term follow-up study in Goto Islands, Japan
- Toxic Shock-like Syndrome Caused by T Serotype B3264 Streptococcus
- Effects of naturally occurring mutations in hepatitis B virus core promoter on transcriptional activity
- Prevalence and Characterization of Hepatitis C Virus in Hemodialysis Patients
- Refractory hepatic hydrothorax treated with transjugular intrahepatic portosystemic shunt
- CD4 T-Cell Regulation of Cytotoxic T Cells During the Induction Phase of Liver-Induced Spontaneous Tolerance in Rats
- Vacuum-assisted biopsy and steroid therapy for granulomatous lobular mastitis: report of three cases.
- In Vivo Assessment of the Regulatory Mechanism of Cholinergic Neuronal Activity Associated With Motility in Dog Small Intestine
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- Analysis of interferon regulatory factor 1 and 2 gene expression in human hepatoma cell lines
- Lens culinaris agglutinin-reactive α-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis : a histopathological study of surgically resected hepatocellular carcinoma
- Comparative Study of C-Reactive Protein in Chronic Hepatitis B and Chronic Hepatitis C
- Attenuated Familial Adenomatous Polyposis Associated with Advanced Rectal Cancer in a 16-Year-Old Boy : Report of a Case
- Small-Cell Carcinoma of the Gallbladder : Report of a Case
- Intrahepatic Cholangiocarcinoma with Extensive Sarcomatous Change: Report of a Case
- Protective effects of a hibernation-inducer on hepatocyte injury induced by hypothermic preservation
- Biliary complications in recipients of living-donor liver transplantation
- Re-analysis of Clinical Features of 89 Patients with Autoimmune Hepatitis Using the Revised Scoring System Proposed by the International Autoimmune Hepatitis Group
- Pancreatic Cancer with Umbilical Metastasis (Sister Mary Joseph's Nodule)
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- In Vivo Assessment of Acceleration of Motor Activity Associated With Acetylcholine Release via 5-Hydroxytryptamine_4 Receptor in Dog Intestine
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- In Vivo Microdialysis Assessment of Nerve-Stimulated Contractions Associated With Increased Acetylcholine Release in the Dog Intestine
- Early development of cavernomatous vasculatures in portal venous thrombosis : morphometric kinetics in rabbit model
- Successful Left Adrenalectomy for Metastatic Hepatocellular Carcinoma Using Hand-Assisted Laparoscopic Surgery : Report of a Case
- Successful Surgical Treatment of Gastric Cancer with a Tumor Thrombus in the Portal and Splenic Veins : Report of a Case
- Localization of Epidermal Growth Factor Receptor Enhancer Protein in A431 Epidermoid Carcinoma Cells by Southwestern Histochemistry (Recent Progress In Gene Histochemistry)
- Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells
- What Is the Real Contribution of Extrahepatic Cells to Liver Regeneration?
- Pleckstrin Homology Domain as an Inositol Compound Binding Module
- The Serum Level of Carcinoembryonic Antigen in Drainage Venous Blood Is Not a Sensitive Predictor of Metachronous Hepatic Metastasis for Patients with Colorectal Cancer
- Detection of Carcinoembryonic Antigen mRNA in the Mesenteric Vein of Patients with Resectable Colorectal Cancer
- Pancreatic Beta-Cell Replication in Streptozotocin-Diabetic Rats : The Effect of Liver Compensatory Growth on Intraportally Engrafted Islets
- Efficacy and limitation of bone marrow transplantation in the treatment of acute and subacute liver failure in rats
- The outcomes of methicillin-resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center
- Living-donor liver transplantation from second generation children for atomic bomb survivors
- Patient allocation based on preoperative assessment of pancreatic fibrosis to secure pancreatic anastomosis performed by trainee surgeons : a prospective study
- Hand-assisted laparoscopic total pancreatectomy for a main duct intraductal papillary mucinous neoplasm of the pancreas.
- Utility of Preoperative Dynamic Magnetic Resonance Imaging of the Pancreas in Diagnosing Tumor-Forming Pancreatitis that Mimics Pancreatic Cancer : Report of a Case
- Intraductal papillary mucinous neoplasm of the pancreas with a bifid pancreatic duct.
- ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C
- A Combination Procedure with Thrombolytic Therapy and Balloon Dilatation for Portal Vein Thrombus Enables the Successful Performance of Antiviral Therapy After a Living-Donor Liver Transplantation : Report of a Case
- Effect of an oral branched chain amino acid-enriched snack in cirrhotic patients with sleep disturbance
- Prediction and management of a low-lying costal arch which restricts the operative working space during laparoscopic cholecystectomy
- Living Donor Liver Transplantation with Extensive Caval Thrombectomy for Acute-on-Chronic Budd-Chiari Syndrome
- Significance of serum β-D-glucan levels in recipients of living donor liver transplantation
- Technical refinements of bile duct division in living donor liver surgery
- Parenchymal leiomyoma of the breast : a case report with special reference to magnetic resonance imaging findings and an update review of literature
- Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan.
- Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells
- Hemophagocytic Syndrome After Liver Transplantation : Report of Two Cases
- Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas : report of a case
- Prevention of gastric stasis by omentum patching after living donor left hepatectomy
- Use of stepwise versus straightforward clamping of biliary drainage tubes after living-donor liver transplantation : a prospective, randomized trial