Clinical Significance of Telomerase Activity and Telomere Length in Various Liver Diseases

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概要

• 論文の詳細を見る

• We investigated the clinical significance of telomerase activity and telomere length in hepatocellular carcinomas (HCCs) and chronic liver diseases. Telomerase activity was assessed quantitatively using 'Stretch PCR' assay and telomere length by Southern blotting in 24 HCCs, 2 focal nodular hyperplasia, 8 liver cirrhosis, 10 chronic hepatitis and 8 histologically normal livers. The latter were obtained from normal sections of resected specimens of cholangiocellular carcinoma, metastatic liver tumor or hemangioma. The relative titers of telomerase activity (RTA) were significantly higher in HCCs (average, 54 units) than in chronic liver diseases (average, 0.6 units) (P<0.001). In comparison, RTA was less than 2 units in non-malignant liver tissues. Telomere length in cirrhotic liver tissues was significantly shorter than in normal livers and tended to be shorter than those in chronic hepatitis. Telomere length and RTA correlated with the grading of tissue derangement in chronic liver diseases. Our results suggest that RTA estimated by Stretch PCR assay might be clinically useful for accurate diagnosis of liver diseases, particularly HCCs. In addition, telomere length seems to having a possibility as a useful predictor for risk of hepatocarcinogenesis.

• 長崎大学の論文

著者

• Kanematsu Takashi

  長崎大学 医歯薬学総合研究科外科

• Kanematsu T

  Division Of Surgery Department Of Translational Medical Sciences Nagasaki University Graduate School

• OKUDAIRA Sadayuki

  Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences

• Kanematsu Takashi

  長崎大学 医歯薬総研究外科学

• Kanematsu Takashi

  Div. Of Surgery Dep. Of Translational Medical Sciences Nagasaki Univ. Graduate School Of Biomedical

• KITAOKA FUMIO

  Second Department of Surgery, Nagasaki University School of Medicine

• Furui Junichiro

  Second Department Of Surgery Nagasaki University School Of Medicine

• Taniyama Kohtaro

  Division Of Pharmacology Department Of Translational Medical Sciences Nagasaki University Graduate S

• Takemura Keiko

  Department Of Pharmacology Nagasaki University School Of Medicine

• Kitaoka Fumio

  Second Department Of Surgery Nagasaki School Of Medicine

• Kanematsu Takashi

  Department Of Transplantation And Digestive Surgery Nagasaki University Graduate School Of Biomedica

• Furui Jun-ichiro

  Second Department Of Surgery Nagasaki University School Of Medicine

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