Regional and Functional Differences of 5-Hydroxytryptamine-Receptor Subtypes in Guinea Pig Stomach
スポンサーリンク
概要
- 論文の詳細を見る
Functions and the presence of 5-hydroxytryptamine (5-HT) receptors in the fundus, corpus and antrum of the guinea pig stomach were examined by measuring contractile force and acetylcholine (ACh) release. Stimulation of the 5-HT1 receptor caused tetrodotoxin (TTX)-insensitive relaxations in the preparations from 3 regions. Stimulation of the 5-HT2 receptor caused TTX-insensitive contractions in the preparations of fundus and antrum. Stimulation of 5-HT3 receptors caused contractions that were sensitive to TTX and atropine and enhanced the outflow of [3H]ACh from preparations of only antrum. Stimulation of 5-HT4 receptors caused contractions of antral strips and decreased relaxations of corporal strips and enhanced the outflow of [3H]ACh from the preparations of both corpus and antrum. In the guinea pig stomach, the fundus possesses relaxant 5-HT1 receptor < contractile 5-HT2 receptors and caused the contractile response to 5-HT. The corpus possesses relaxant 5-HT1 receptors and relaxant receptors other than 5-HT1, 5-HT2, 5-HT3 and 5-HT4 receptors > contractile 5-HT4 receptor, and therefore 5-HT caused relaxations. The antrum possesses relaxant 5-HT1 receptor < contractile 5-HT2, 5-HT3 and 5-HT4 receptors, and thus 5-HT caused contractions.
- 社団法人 日本薬理学会の論文
著者
-
Kanematsu T
Division Of Surgery Department Of Translational Medical Sciences Nagasaki University Graduate School
-
Kanematsu Takashi
長崎大学 医歯薬総研究外科学
-
Kanematsu Takashi
Div. Of Surgery Dep. Of Translational Medical Sciences Nagasaki Univ. Graduate School Of Biomedical
-
TANIYAMA Kohtaro
Departments of Pharmacology
-
Taniyama K
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
-
Kaibara Muneshige
Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences
-
Taniyama Kohtaro
Division Of Pharmacology Department Of Translational Medical Sciences Nagasaki University Graduate S
-
Taniyama Kohtaro
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
-
Taniyama K
Division Of Pharmacology Department Of Translational Medical Sciences Nagasaki University Graduate S
-
Takemura Keiko
Department Of Pharmacology Nagasaki University School Of Medicine
-
Takada Kohei
Department Of Aerospace Engineering Tokyo Metropolitan University
-
MAMEYA Shunichi
Department of Pharmacology, Nagasaki University School of Medicine
-
Kaibara Muneshige
Department Of Pharmacology Nagasaki University School Of Medicine
-
Kaibara Muneshige
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
-
Mameya Shunichi
Department Of Pharmacology Nagasaki University School Of Medicine
-
Takeda Kohei
Department Of Mechanical Engineering Aichi Institute Of Technology
-
Takeda Kohei
Department of Chemistry, Nagaoka University of Technology
-
Taniyama Kohtaro
Department of Pharmacology 2, Nagasaki University School of Medicine
関連論文
- Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation.
- Hepatitis C virus kinetics during the first phase of pegylated interferon-alpha-2b with ribavirin therapy in patients with living donor liver transplantation.
- Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver.
- A secure taping technique for a liver hanging maneuver using a surgical probe.
- Re-evaluation of lipiodolized transarterial chemoembolization therapy for intrahepatic recurrence of hepatocellular carcinoma after curative liver resection.
- Compressive stenosis of the inferior vena cava due to localized ascites after living-donor liver transplantation.
- Evolution of living donor liver transplantation over 10 years: experience of a single center.
- Inactivation of porcine endogenous retrovirus by human serum as a function of complement activated through the classical pathway
- A new suppressive agent against interleukin-1β and tumor necrosis factor-α enhances liver regeneration after partial hepatectomy in rats
- An Unusual Perforation of the Colon : Report of Two Cases
- Impaction of a Shrapnel Splinter in the Common Bile Duct After Migrating from the Right Thoracic Cavity : Report of a Case
- Hepatic expression and serum levels of thrombomodulin reflect the extent of liver injury in rats with fulminant hepatic failure and extensive hepatectomy
- Successful Repeated Transcatheter Arterial Embolization (TAE) for Multiple Liver Metastases from Breast Cancer
- I1-5 Role of intrasplenic hepatocyte transplantation in preventing postoperative liver failure in cirrhotic rats.
- The Fas/Fas-ligand system functions in hepatocytes in the early stage of fulminant hepatic failure in rats
- Presence of GABA_B Receptors Forming Heterodimers With GABA_ and GABA_ Subunits in Human Lower Esophageal Sphincter
- Effect of the C3a-Receptor Antagonist SB 290157 on Anti-OVA Polyclonal Antibody—Induced Arthritis
- Intraoperative pancreatography and gastric-wall-covering method for the prevention of pancreatic leakage after enucleation of insulinoma in the pancreas
- Common Fragile Genes and Digestive Tract Cancers
- Hepatolithiasis and intrahepatic cholangiocarcinoma : carcinogenesis based on molecular mechanisms
- Parapapillary choledochoduodenal fistula associated with cholangiocarcinoma
- Genetic Alterations in Gallbladder Carcinoma
- Role of Hypermethylation on Carcinogenesis in the Pancreas
- Utilization of Jejunal Segment has Benefit for Reconstruction of the Extrahepatic Bile Duct in the Canine
- Ruptured Aneurysm of the Visceral Artery : Report of Two Cases
- CD4 T-Cell Regulation of Cytotoxic T Cells During the Induction Phase of Liver-Induced Spontaneous Tolerance in Rats
- Hepatic resections for bilobar liver metastases from colorectal cancer
- Effective Treatment of Liver Metastases from Colon Cancer with a Combination of γ-Interferon and Cisplatin Chemotherapy : Report of a Case
- In Vivo Assessment of the Regulatory Mechanism of Cholinergic Neuronal Activity Associated With Motility in Dog Small Intestine
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- MRI facilitated a diagnosis of endometriosis of the rectum
- μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB_1 Receptor : Electrophysiological and FRET Assay Analysis
- Gastric Necrosis After an Infarction of the Spleen : Report of a Case
- Attenuated Familial Adenomatous Polyposis Associated with Advanced Rectal Cancer in a 16-Year-Old Boy : Report of a Case
- Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats
- Histologicak Evience for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats
- Protective effects of a hibernation-inducer on hepatocyte injury induced by hypothermic preservation
- Biliary complications in recipients of living-donor liver transplantation
- PJ-357 Over Expressed Beta Subunit Masked Regulation of Ca^ Channel by A-kinase Mediated Phosphorylation(Molecular Biology, Myocardium 1 (M) : PJ60)(Poster Session (Japanese))
- Inhibition by γ-Aminobutyric Acid System Activation of Epileptic Seizures in Spontaneously Epileptic Rats
- GTPγS-Induced Ca^ Activated C1^- Currents: Its Stable Induction by Gqα Overexpression in Xenopus Oocytes
- Characterization of GABA_B Receptors Involved in Inhibition of Motility Associated With Acetylcholine Release in the Dog Small Intestine : Possible Existence of a Heterodimer of GABA_ and GABA_ Subunits
- Characterization of GABA_B Receptor in the Human Colon
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- In Vivo Assessment of Acceleration of Motor Activity Associated With Acetylcholine Release via 5-Hydroxytryptamine_4 Receptor in Dog Intestine
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- A second primary esophageal cancer developing 7 years after chemoradiotherapy for advanced esophageal cancer
- Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine-4 receptor, in gastrointestinal motility
- Tetanus After a Resection for a Gangrenous Perforated Small Intestine: Report of a Case
- Ability of Mosapride to Bind to 5-HT_4 Receptor in the Human Stomach
- In Vivo Microdialysis Assessment of Nerve-Stimulated Contractions Associated With Increased Acetylcholine Release in the Dog Intestine
- Successful Left Adrenalectomy for Metastatic Hepatocellular Carcinoma Using Hand-Assisted Laparoscopic Surgery : Report of a Case
- Clinical Significance of Telomerase Activity and Telomere Length in Various Liver Diseases
- A Free Jejunal Reconstruction Following the Failure of an Initial Esophageal Reconstruction with Colic Pedicle - Report of a Case
- Successful Surgical Treatment of Gastric Cancer with a Tumor Thrombus in the Portal and Splenic Veins : Report of a Case
- Localization of Epidermal Growth Factor Receptor Enhancer Protein in A431 Epidermoid Carcinoma Cells by Southwestern Histochemistry (Recent Progress In Gene Histochemistry)
- Propofol Inhibits Muscarinic Acetylcholine Receptor-Mediated Signal Transduction in Xenopus Oocytes Expressing the Rat M1 Receptor
- Two distinct inactivation processes related to phosphorylation in cardiac L-type Ca^ channel currents
- Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca^ Influx in Cultured Bovine Adrenal Chromaffin Cells
- The Serum Level of Carcinoembryonic Antigen in Drainage Venous Blood Is Not a Sensitive Predictor of Metachronous Hepatic Metastasis for Patients with Colorectal Cancer
- Detection of Carcinoembryonic Antigen mRNA in the Mesenteric Vein of Patients with Resectable Colorectal Cancer
- Increases in Serum Nitrite and Nitrate of a New-Fold Adversely Affect the Outcome of Pregnancy in Rats
- Regional and Functional Differences of 5-Hydroxytryptamine-Receptor Subtypes in Guinea Pig Stomach
- Facilitation of Acetylcholine Release by SK-951, a Benzofuran Derivative, via the 5-Hydroxytryptamine_4 Receptor in Guinea Pig Stomach
- Identification of SK-951, a Novel Benzofuran Derivative, as an Agonist to 5-HT_4 Receptors
- IS-12 Thoracoscopic Diaphragmatic Procedures under Artificial Pneumothorax(International Session III)
- Interaction between human periodontal ligament cells and slices of dentin in a three-dimensional culture
- Congenital dilatation of the bile duct : Changes in diagnostic tools over the past 19 years
- Efficacy and limitation of bone marrow transplantation in the treatment of acute and subacute liver failure in rats
- The outcomes of methicillin-resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center
- Living-donor liver transplantation from second generation children for atomic bomb survivors
- Patient allocation based on preoperative assessment of pancreatic fibrosis to secure pancreatic anastomosis performed by trainee surgeons : a prospective study
- Hand-assisted laparoscopic total pancreatectomy for a main duct intraductal papillary mucinous neoplasm of the pancreas.
- Utility of Preoperative Dynamic Magnetic Resonance Imaging of the Pancreas in Diagnosing Tumor-Forming Pancreatitis that Mimics Pancreatic Cancer : Report of a Case
- Intraductal papillary mucinous neoplasm of the pancreas with a bifid pancreatic duct.
- A Combination Procedure with Thrombolytic Therapy and Balloon Dilatation for Portal Vein Thrombus Enables the Successful Performance of Antiviral Therapy After a Living-Donor Liver Transplantation : Report of a Case
- Receding Horizon Control on Steering of Control Moment Gyro for Fast Attitude Maneuver
- Activation of a Potassium Conductance by Extracellular Alkaline pH in Oocytes of Xenopus laevis
- 5-Hydroxytryptamine Receptors, Especially the 5-HT_4 Receptor, in Guinea Pig Urinary Bladder
- MODIFICATION OF THE TONUS AND DRUG-INDUCED CONTRACTION OF THE ISOLATED RAT ILEUM BY REMOVAL OF Na FROM BATHING MEDIA
- INFLUENCES OF AMINOPHYLLINE AND REDUCTION IN EXTERNAL Na ON THE ANTISPASMODIC ACTION OF ISOPROTERENOL IN THE ISOLATED RAT RECTUM
- Prediction and management of a low-lying costal arch which restricts the operative working space during laparoscopic cholecystectomy
- Living Donor Liver Transplantation with Extensive Caval Thrombectomy for Acute-on-Chronic Budd-Chiari Syndrome
- Significance of serum β-D-glucan levels in recipients of living donor liver transplantation
- Technical refinements of bile duct division in living donor liver surgery
- ACTIONS OF Ba AND Sr IONS ON ISOLATED RAT ILEUM
- Adaptive Skewing Pyramid-type CMGs for Fast Attitude Maneuver
- Parenchymal leiomyoma of the breast : a case report with special reference to magnetic resonance imaging findings and an update review of literature
- Mechanism of Inhibitory Actions of Geranium thunbergii, Tannic Acid and Geraniin on the Motility of Rat Intestine
- Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan.
- Hemophagocytic Syndrome After Liver Transplantation : Report of Two Cases
- Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas : report of a case
- Increases in Serum Nitrite and Nitrate of a Few-Fold Adversely Affect the Outcome of Pregnancy in Rats
- Prevention of gastric stasis by omentum patching after living donor left hepatectomy
- Use of stepwise versus straightforward clamping of biliary drainage tubes after living-donor liver transplantation : a prospective, randomized trial
- Mechanism of contractile response to Mn ion in isolated rat rectum.
- Irreversible inhibitory effect of atropine on contractile responses to drugs in isolated rabbit ileum.
- Cyclic adenosine 3',5'-monophosphate levels in response to norepinephrine in rectum of postnatal rats.
- Effects of MPC-1304, a Novel Calcium Antagonist, on Stroke-Prone Spontaneously Hypertensive Rats
- Expression of the Endothelin Receptors in the Hippocampus of SHRSP after Transient Forebrain Ischemia