Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca^<2+> Influx in Cultured Bovine Adrenal Chromaffin Cells
スポンサーリンク
概要
- 論文の詳細を見る
Selenium is an essential trace metal element, whereas large doses of selenium exert adverse effects to the human body. We examined the effects of selenium compounds, sodium selenite (Na2SeO3) and sodium selenate (Na2SeO4), on catecholamine secretion from cultured bovine adrenal chromaffin cells. Treatment of chromaffin cells with sodium selenite for 72, 48, and 24 h caused decreases in protein and catecholamine contents, in association with cell damage, at concentrations over 30, 300, and 300 μM, respectively. The cells treated with subtoxic conditions (<100 μM, 48 h) of sodium selenite were used for further experiments. Sodium selenite treatment for 48 h inhibited carbachol (CCh)-induced catecholamine secretion in a concentration-dependent and non-competitive manner, while it did not affect high K+- and veratridine-induced catecholamine secretion. Sodium selenite (100 μM) did not affect CCh- and veratridine-induced 22Na+ influx, while the compound inhibited 45Ca2+ influx induced only by CCh, but not high K+ and veratridine. Sodium selenate even at higher concentrations (1000 μM) did not affect any stimulus-induced catecholamine secretion and 45Ca2+ influx. Thus, sodium selenite may specifically exert adverse effects, such as inhibition of physiological stimulus-induced catecholamine secretion from adrenal chromaffin cells due to inhibition of Ca2+ influx.
- 社団法人 日本薬理学会の論文
- 2006-07-20
著者
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Yanagihara Nobuyuki
Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health
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TANIYAMA Kohtaro
Departments of Pharmacology
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WADA Akihiko
Department of Radiology, Shimane Medical College
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UEZONO Yasuhito
Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences
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Uezono Yasuhito
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Uezono Yasuhito
Department Of Pharmacology Ii School Of Medicine Nagasaki University
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Taniyama Kohtaro
Department Of Pharmacology Nagasaki University Graduate School Of Biomedical Sciences
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Yanagihara Nobuyuki
Department Of Phamacology University Of Occupational And Environmental Health
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Yanagihara Nobuyuki
Department Of Pharmacology University Of Occupational And Environmental Health School Of Medicine
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Wada Akihiko
Department Of Pharmacology Miyazaki Medical College University Of Miyazaki
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Wada Akihiko
Department Of Hygiene Fujita Health University Of Medicine
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TOYOHIRA Yumiko
Department of Phamacology, University of Occupational and Environmental Health
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Toyohira Yumiko
Department Of Phamacology University Of Occupational And Environmental Health
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Toyohira Yumiko
Department Of Pharmacology University Of Occupational And Environmental Health School Of Medicine
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Uezono Yasuhito
Department of Molecular and Cellular Biology Nagasaki University Graduate School of Biomedical Sciences, Japan
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Taniyama Kohtaro
Department of Pharmacology 2, Nagasaki University School of Medicine
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