Pharmacological Aspects of the Effects of Tramadol on G-Protein Coupled Receptors
スポンサーリンク
概要
- 論文の詳細を見る
Tramadol is an analgesic that is used worldwide, but its mechanisms of action have not been elucidated. It has been speculated that tramadol acts primarily through the activation of μ-opioid receptors and the inhibition of monoamine reuptake. The majority of studies to date have focused on ion channels in the central nervous system as targets of anesthetics and analgesics. During the past decade, major advances have been made in our understanding of the physiology and pharmacology of G-protein coupled receptor (GPCR) signaling. Several studies have shown that GPCRs and ion channels are targets for analgesics and anesthetics. In particular, tramadol has been shown to affect GPCRs, including muscarinic acetylcholine receptors and 5-hydroxytryptamine receptors. Here, the effects of tramadol on monoamine transporters, GPCRs, and ion channels are presented, and recent research on the pharmacology of tramadol is discussed.
- 社団法人 日本薬理学会の論文
- 2007-03-20
著者
-
Uezono Yasuhito
Department Of Pharmacology Ii School Of Medicine Nagasaki University
-
Ueta Yoichi
Department Of Medicine University Of Bristol Bristol Royal Infirmary
-
MINAMI Kouichiro
Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicin
-
Minami Kouichiro
Department Of Anesthesiology And Critical Care Medicine Jichi Medical University
-
Uezono Yasuhito
Department of Molecular and Cellular Biology Nagasaki University Graduate School of Biomedical Sciences, Japan
-
Minami Kouichiro
Department of Anesthesiology and Critical Care Medicine, Jichi Medical University
関連論文
- Hypothalamic Neuropeptides and Appetite Response in Anorexia-Cachexia Animal
- Nitric Oxide Synthases and Cardiovascular Diseases : Insights From Genetically Modified Mice
- μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB_1 Receptor : Electrophysiological and FRET Assay Analysis
- Adrenomedullin, an Autocrine Mediator of Blood-Brain Barrier Function
- Reduced Carnitine Level Causes Death from Hypoglycemia : Possible Involvement of Suppression of Hypothalamic Orexin Expression During Weaning Period
- GTPγS-Induced Ca^ Activated C1^- Currents: Its Stable Induction by Gqα Overexpression in Xenopus Oocytes
- Sequential changes in transforming growth factor (TGF)-β1 concentration in synovial fluid and mRNA expression of TGF-β1 receptors in chondrocytes after immobilization of rabbit knees
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- Propofol Inhibits Muscarinic Acetylcholine Receptor-Mediated Signal Transduction in Xenopus Oocytes Expressing the Rat M1 Receptor
- The Tramadol Metabolite O-Desmethyl Tramadol Inhibits Substance P–Receptor Functions Expressed in Xenopus Oocytes
- Obstructive Sleep Apnea-hypopnea Syndrome Patients with Overweight and Hypertension in a Japanese Workplace
- Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca^ Influx in Cultured Bovine Adrenal Chromaffin Cells
- Derived (Mutated)–Types of TRPV6 Channels Elicit Greater Ca2+ Influx Into the Cells Than Ancestral-Types of TRPV6: Evidence From Xenopus Oocytes and Mammalian Cell Expression System
- Upregulation of synapsin IIa and IIb mRNAs in the paraventricular and supraoptic nuclei in chronic salt loaded and lactating rats
- A Novel Angiotensin II-Receptor Antagonist, 606A, Induces Regression of Cardiac Hypertrophy, Augments Endothelium-Dependent Relaxation and Improves Renal Function in Stroke-Prone Spontaneously Hypertensive Rats
- Does Recurrent Inhibition Exist in the Paraventricular Magnocellular Neurosecretory Cells in the Male Rat?
- Chaos of Vowel /a/ in Japanese Patients with Depression : A Preliminary Study
- Analysis of the Effects of Anesthetics and Ethanol on μ-Opioid Receptor
- Adrenomedullin Inhibits the Pressor Effects and Decrease in Renal Blood Flow Induced by Norepinephrine or Angiotensin II in Anesthetized Rats
- Pharmacological Aspects of the Effects of Tramadol on G-Protein Coupled Receptors
- Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats
- General anesthesia for progressive external ophthalmoplegia syndrome
- Water deprivation in the rat induces nitric oxide synthase (NOS) gene expression in the hypothalamic paraventricular and supraoptic nuclei
- Comparative Study of TA-606, a Novel Angiotensin II Receptor Antagonist, With Losartan in Terms of Species Difference and Orthostatic Hypotension
- Diurnal Changes of Arginine Vasopressin-Enhanced Green Fluorescent Protein Fusion Transgene Expression in Rat Suprachiasmatic Nucleus
- Combined spinal-epidural anesthesia for cesarean section in a patient with Takayasu arteritis complicated by heart failure
- Effects of sevoflurane on voltage-gated sodium channel Na_v1.8, Na_v1.7, and Na_v1.4 expressed in Xenopus oocytes
- Derived (Mutated)-Types of TRPV6 Channels Elicit Greater Ca^ Influx Into the Cells Than Ancestral-Types of TRPV6 : Evidence From Xenopus Oocytes and Mammalian Cell Expression System
- The Tramadol Metabolite O-Desmethyl Tramadol Inhibits Substance P-Receptor Functions Expressed in Xenopus Oocytes