Nitric Oxide Synthases and Cardiovascular Diseases : Insights From Genetically Modified Mice
スポンサーリンク
概要
- 論文の詳細を見る
Nitric oxide (NO) is produced in almost all tissues and organs, exerting a variety of biological actions under both physiological and pathological conditions. NO is synthesized by 3 distinct NO synthase (NOS) isoforms (neuronal, inducible, and endothelial NOS), all of which are expressed in the human cardiovascular system. The regulatory roles of NOSs in cardiovascular diseases have been described in pharmacological studies with selective and non-selective NOS inhibitors. However, the specificity of the NOS inhibitors continues to be an issue of debate. To overcome this issue, genetically engineered animals have been used. All types of NOS gene-deficient (knockout: KO) animals, including singly, doubly, and triply NOS-KO mice, and various types of NOS gene-transgenic (TG) animals, including conditional and non-conditional TG mice bearing endothelium-specific or cardiomyocyte-specific overexpression of each NOS gene, have thus far been developed. The roles of individual NOS isoforms, as well as the entire NOS system, in the cardiovascular system have been extensively investigated in those mice, and the results provide pivotal insights into the pathophysiology of NOSs in human cardiovascular diseases. Based on studies with murine NOS genetic models, this review summarizes the latest knowledge of NOSs and cardiovascular diseases. (Circ J 2009; 73: 986-993)
- 社団法人 日本循環器学会の論文
- 2009-05-20
著者
-
下川 宏明
東北大学循環器内科学
-
OTSUJI Yutaka
Second Department of Internal Medicine, University of Occupational and Environmental Health
-
SASAGURI Yasuyuki
Department of Pathology, Kurume University School of Medicine
-
Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
-
Sato Hitoshi
Sports Clinic Juntendo University Hospital
-
Shimokawa Hiroaki
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Shimokawa Hiroaki
Juntendo Sports Clinic Juntendo University Hospital
-
Otsuji Yutaka
Department of Cardiology, Kagoshima University
-
Sasaguri Yasuyuki
Department Of Pathology School Of Medicine University Of Occupational And Environmental Health
-
Tsutsui Masato
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
-
Shimokawa H
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Yanagihara Nobuyuki
Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health
-
Otsuji Yutaka
Department Of Internal Medicine School Of Medicine University Of Occupational And Environmental Heal
-
Yanagihara N
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
-
UETA YOICHI
Department of Physiology, School of Medicine, University of Occupational and Environmental Health
-
Sasaguri Yasuyuki
Department Of Pathology And Cell Biology School Of Medicine University Of Occupational And Environme
-
MATSUMOTO TETSURO
Japanese Research Group for UTI
-
Yanagihara Nobuyuki
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
-
Yanagihara Nobuyuki
Department Of Phamacology University Of Occupational And Environmental Health
-
Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
-
Shimokawa Hiroaki
Kyushu University Graduate School Of Medical Sciences
-
Tsutsumi Masato
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
-
Ueta Yoichi
Department Of Medicine University Of Bristol Bristol Royal Infirmary
-
Otsuji Yutaka
Department Of Cardiology And Nephrology University Of Occupational & Environmental Health
-
Miura Tetsuya
Division Of Urology Kobe University Graduate School Of Medicine
-
Tsutsui Masato
Department Of Dermatology Asahikawa Medical College
-
Nakashima Yasuhide
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
-
Nakashima Yasuhide
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
-
Shimokawa Hiroaki
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Science
-
Tsutsui Masato
Department Of Pharmacology University Of Occupational And Environmental Health
-
Suzuka Hiroshi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
-
Otuji Yutaka
Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environment
-
Matsumoto Tetsuro
Japanese Society Of Chemotherapy (jsc)
-
Muratani Tetsuro
Department Of Urology University Of Occupational And Environmental Health
-
Otsuji Yutaka
The Second Department Of Internal Medicine University Of Occupational And Environmental Health Japan
-
Sasaguri Yasuyuki
Department Of Pathology Ii School Of Medicine University Of Occupational And Environmental Health
-
Shimokawa Hiroaki
From Reseach Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Unive
-
Otsuji Yutaka
Department Of Internal Medicine School Of Medicine University Of Occupational And Environmental Heal
-
Sasaguri Yasuyuki
Department Of Pathology And Cell Biology School Of Medicine University Of Occupational And Environme
-
Sasaguri Yasuyuki
Department Of Pathology And Cell Biology School Of Medicine University Of Occupational And Environme
-
Sasaguri Yasuyuki
Department Of Pathology And Cell Biology School Of Medicine University Of Occupational And Environme
-
Nakashima Yasuhide
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
-
TSUTSUI Masato
Department of Cardiology, Iizuka Hospital
関連論文
- 冠攣縮性狭心症の診断と治療に関するガイドライン(ダイジェスト版,循環器病の診断と治療に関するガイドライン(2006-2007年度合同研究班報告))
- 冠攣縮性狭心症の診断と治療に関するガイドライン(循環器病の診断と治療に関するガイドライン(2006-2007年度合同研究班報告))
- 冠攣縮性狭心症の診断と治療に関するガイドライン
- Off-pump CABG直後に発症した重症冠動脈れん縮に対しPho-kinase inhibitorが著効した一症例(第94回日本循環器学会九州地方会)
- NO合成酵素完全欠損マウスの開発
- Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris
- 血管!発見!物語(9)血管病へのRho-kinaseの関与
- 心腎連関と貧血・エリスロポエチン(5.高血圧と脳・心・腎連関,第72回日本循環器学会学術集会)
- 冠攣縮性狭心症診療の現状と問題点(3.冠攣縮を見直す,第72回日本循環器学会学術集会)
- 虚血性心疾患 : 診断と治療の進歩
- 14)血栓塞栓による急性心筋梗塞を発症した先天性心疾患根治術後の2例(第143回日本循環器学会東北地方会)
- 9)狭心症状を呈した左冠動脈再建術後20年以上経過したBland White Garland症候群の2例(第143回日本循環器学会東北地方会)
- 17)当科におけるCypher Stentの使用成績と再狭窄例の検討(第142回日本循環器学会東北地方会)
- DP-080-4 肝硬変合併門脈圧亢進症に対するFasudil(Rho-kinase inhibitor)の有効性とその分子機序(第107回日本外科学会定期学術集会)
- 肝硬変症に対するRho-kinase阻害薬・fasudilを用いた治療法の開発
- ウサギ慢性虚血肢モデルにおける低出力体外衝撃波を用いた非侵襲性血管新生療法に関する研究(第105回日本外科学会定期学術集会)
- 肝虚血再灌流障害に関与するRho-kinase シグナル伝達系の検討(第105回日本外科学会定期学術集会)
- SF-047-3 ラット肝硬変モデルの肝内微小循環障害に関与するRho-rho kinaseシグナル伝達系の検討
- PD-14-2 門脈圧亢進症における分子機序解明と治療への展開
- SY-9-2 遺伝子治療,体外衝撃波治療による血管新生療法の開発と血行再建術後療法としての展開
- SY-2-7 Dominant negative Rho-kinaseを用いた肝冷保存後再潅流傷害のメカニズムの解明と遺伝子治療の可能性 : Reactive oxygen species(ROS)抑制効果
- Rho kinase inhibitorによる肝移植後虚血再潅流傷害抑制効果
- Rhoキナーゼ研究の進展と阻害剤の将来展望
- 循環器疾患と Rho キナーゼ
- 心腎貧血連関とエリスロポエチン (特集 心疾患診療の"トピックス")
- Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
- Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan : Report From the MIYAGI-AMI Registry Study
- Evidence for Rho-Kinase Activation in Patients With Pulmonary Arterial Hypertension
- PJ-477 Diagnostic Usefulness of Vasodilator Test with Inhaled Nitric Oxide in Patients with Pulmonary Veno-Occlusive Disease(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- PE-445 Renin-Angiotensin System Plays an Important Role in Diabetes Mellitus-Induced Diastolic Dysfunction in Hypertensive Rats(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- PE-444 Prognostic Impact of Myocardial Fibrosis in Systolic Heart Failure : New Aspect of Usefulness of Myocardial Biopsy(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-349 Gender Difference in the Responsiveness to Corticosteroid Therapy in Patients with Cardiac Sarcoidosis(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-129 Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice(PE022,Atherosclerosis, Basic (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Optical Coherence Tomography as a Novel Diagnostic Tool for Distal Type Chronic Thromboembolic Pulmonary Hypertension
- ファスジルによるRhoキナーゼ阻害が狭心症発作に有効であった安静時狭心症の1例
- 97) 感染性心内膜炎によって生じたと考えられる「左室-右房交通症」の一例(第95回日本循環器学会九州地方会)
- 延髄孤束核における循環調節に及ぼす Rho/Rho-kinase 系の役割
- 74) 急性期にタコツボ型の左室収縮不全を認め,回復期のアセチルコリン負荷で冠微小循環不全が疑われた一例(第96回日本循環器学会九州地方会)
- 疾患の理解編 (疾患と看護がわかる看護過程 ナーシングプロセス 狭心症)
- 135) バージャー病としては非典型的な病像を呈した末梢動脈疾患の一例(第95回日本循環器学会九州地方会)
- 15) ドブタミン負荷心エコー後に発症した急性心筋梗塞の一例(第95回日本循環器学会九州地方会)
- 2) LMT相当病変のAMIに対してPCPS下のYステントにて救命し得た症例(第96回日本循環器学会九州地方会)
- 下肢動脈狭窄病変を伴った左主幹部相当病変による心原性ショックに対しIABP・PCPS下に急性期血行再建を行った1例
- NO/活性酸素による血管シグナル伝達機構 (特集 活性酸素・フリーラジカル機能と病態解明への新たなる展開 バイオスピンとシグナル伝達)
- EDHF(基礎科学の進歩)
- ナノ医療の臨床への展開
- 15) 無症状で発見された右内胸動脈-肺動脈瘻の一例(第96回日本循環器学会九州地方会)
- 1 Current Status of Vasospastic Angina in Japan : An Interim-report of the Multicenter Registry of the Coronary Spasm Association of Japan(Recent Progress in the Management of Vasospastic Angina,Meet the Expert 6 (ME-6) (IHD),The 73rd Annual Scientific Me
- Importance of Dual Induction Tests for Coronary Vasospasm and Ventricular Fibrillation in Patients Surviving Out-of-Hospital Cardiac Arrest
- FRS-082 Features and Preliminary Results of the Multicenter Registry of the Coronary Spasm Association(FRS17,Novel Approaches to Treatment of CAD (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- 1 Importance of Medical Treatment for Vasospastic Angina : Lessons from Multicenter Registry by Coronary Spasm Association of Japan(Therapeutic Decision Making for Coronary Artery Disease Among PCI, CABG, and Medication,Symposium 3 (SY-03) (IHD),The 73rd
- Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats
- PJ-171 Pravastatin Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension Through Down-regulation of Stromal Cell-Derived Factor-1 in Mice(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- PE-171 Co-existence of Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest(PE029,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy
- PJ-731 Genetic Disruption of All Nitric Oxide Synthase Isoforms Causes Accelerated Renal Lesion Formation in Mice in Vivo(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- PJ-693 Inhibition of Sodium Channels Enhances Arrhythmogenic Regional Endocardial Substrate in Patients with Brugada Syndrome(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The J
- PJ-533 Role of H_2O_2 as an Endogenous EDHF during Coronary Occlusion and Injection of Erythropoietin in Canine Coronary Native Collateral Microvessels(PJ090,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Poster Session (Japanese),Th
- PJ-234 Usefulness of Cardiac Magnetic Resonance Imaging to Evaluate Cardiac Dyssynchrony in Patients with Chronic Heart Failure(PJ040,CRT/ICD 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-188 Combination Therapy with an Angiotensin Receptor Blocker and a Calcium Channel Blocker Improves EDHF-Mediated Responses in Diabetic Apolipoprotein E-Deficient Mice(PJ032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 1 (H),Poster
- PE-451 Extracorporeal Cardiac Shock Wave Therapy Ameliorates Left Ventricular Remodeling after Myocardial Ischemia-Reperfusion Injury in Pigs in Vivo(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circul
- OJ-046 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension(OJ08,Pulmonary Circulation (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 3 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 5 Differential Roles of Progenitor Cells in the Arterial Development of the Abnormal Vasculature(Young Investigator's Award Finalists Lectures (YIA),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-100 Role of Rho-kinase in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Paclitaxel-Eluting Stent(OE17,Coronary Revascularization, PCI (Restenosis/Others/DES) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- 3 Protective Role of Endogenous Erythropoietin-erythropoietin Receptor System in the Development of Heart Failure(The Mechanism and Management of Cardio-renal Risk,Roundtable Discussion 3 (RT-3) (H),The 73rd Annual Scientific Meeting of The Japanese Circu
- Emerging Problems of Heart Failure Practice in Japanese Women : Lessons From the CHART Study
- PJ-249 Crucial Role of H_2O_2 as an Endogenous EDHF and Erythropoietin during Acute Coronary Occlusion in Canine Collateral Microvessels in Vivo(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of t
- 5 Current Status and Future Perspectives of Diastolic Heart Failure in Japan : Possible Importance of Metabolic Syndrome(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annual Scie
- Combination Therapy With Olmesartan and Azelnidipine Improves EDHF-Mediated Responses in Diabetic Apolipoprotein E-Deficient Mice
- 冠動脈攣縮の分子機序--Rhoキナーゼをターゲットとした冠動脈攣縮に対するあらたな治療戦略の可能性 (第1土曜特集 虚血性心疾患--分子メカニズムの理解から新しい治療へ) -- (病態生理の理解)
- 1 Central Obesity is a Significant Risk Independent of Insulin Resistance in the Development of Cardiovascular Disease(Key Players of Metabolic Syndrome,Symposium 4 (SY-04) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-206 Long-Term Treatment with Eicosapentaenoic Acid Suppresses Ischemia-Induced Ventricular Fibrillation in Pigs in Vivo : Possible Involvement of ATP-Sensitive Potassium (KATP) Channel(PE035,Cardiovascular Pharmacology (Basic) (H),Poster Session (Engli
- PJ-033 Long-Term Treatment with Eicosapentaenoic Acid Suppresses Ventricular Fibrillation in Acute Myocardial Infarction in Pigs : Evaluation with Monophasic Action Potential(Arrhythmia, therapy(23)(A),Poster Session(Japanese),The 72nd Annual Scientific M
- Nitric Oxide Synthases and Cardiovascular Diseases : Insights From Genetically Modified Mice
- PE-259 Mechanisms for the Different Functions of Endothelial Nitric Oxide Synthases System between Conduit and Resistance Arteries in Mice(PE044,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- PE-188 Characterization of Vascular Function in Mice Lacking Entire Nitric Oxide Synthase System(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circula
- OJ-238 Penetration Rate of Standard Treatment in Japanese Patients with Chronic Heart Failure : Interim Analysis of the CHART-2 Study(OJ40,Preventive Medicine/Epidemiology/Education (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of Th
- PJ-744 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertention(Pulmonary circulation(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-567 Prognostic Impact of Main Pulmonary Artery Remodeling in Patients with Pulmonary Arterial Hypertension(Pulmonary circulation(02)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-563 Acute Vasodilator Effects of Inhaled Fasudil, a Specific Rho-Kinase Inhibitor, in Ptients with Pulmonary Arterial Hypertension(Pulmonary circulation(02)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- PJ-095 Endothelium-Dependent Hyperpolarizations are Totally Dependent on Endothelial Nitric Oxide Synthases System : Lessons from Mice Lacking All Nitric Oxide Synthase Isoforms(Endothelium(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meet
- OE-111 New Additional Prognostic Factors of Pulmonary Hypertension : Lessons from Long-Term Follow-Up Study(OE19,Pulmonary Circulation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-359 Severe Dyslipidemia and Lipid-Rich Atherosclerotic Lesion Formation in Mice Lacking All Nitric Oxide Synthases Fed a High-Cholesterol Diet(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circu
- OE-197 Left Ventricular Hypertrophy and Diastolic Dysfunction in Mice Lacking All Nitric Oxide Synthase Isoforms(OE34,Cardiac Function (Basic) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-012 Genetic Disruption of Entire Nitric Oxide Synthase System Causes Activation of Renin-Angiotensin-Aldosterone Axis in Mice in Vivo(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- Importance of Rac1 Signaling Pathway Inhibition in the Pleiotropic Effects of HMG-CoA Reductase Inhibitors(Vascular Medicine)
- PJ-634 Assessment of Delayed Enhancement Scoring on MRI in Patients with Cardiac Sarcoidosis with Implantable Cardioverter Defibrillator(Cardiomyopathy, basic / clinical(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
- Identification of New Prognostic Factors of Pulmonary Hypertension
- Prevalence and Clinical Implication of Metabolic Syndrome in Chronic Heart Failure : Report From MetS-CHF Study
- 循環器領域における性差医療に関するガイドライン
- Hypertension Promotes Phosphorylation of Focal Adhesion Kinase and Proline-Rich Tyrosine Kinase 2 in Rats : Implication for the Pathogenesis of Hypertensive Vascular Disease
- 循環器領域における次世代非侵襲性医療の開発
- 次世代低侵襲性医療の開発
- Spontaneous Development of Left Ventricular Hypertrophy and Diastolic Dysfunction in Mice Lacking All Nitric Oxide Synthases
- Acceleration of Ca^ Waves in Monocrotaline-Induced Right Ventricular Hypertrophy in the Rat
- Long-Term Treatment With Eicosapentaenoic Acid Ameliorates Myocardial Ischemia-Reperfusion Injury in Pigs In Vivo : Involvement of Rho-Kinase Pathway Inhibition
- 内皮由来過分極反応は内皮NO合成酵素系に依存する (第5土曜特集 Vascular Biology Update) -- (血管トーヌスの調整)
- 冠攣縮が関係した院外心停止蘇生例の特徴とその予後 : 冠攣縮研究会レジストリ解析結果より(3.心臓突然死の現状と対策,第74回日本循環器学会学術集会)
- A Sodium Channel Blocker, Pilsicainide, Produces Atrial Post-Repolarization Refractoriness through the Reduction of Sodium Channel Availability